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- NCIT_C121537 IAO_0000115 "A preparation of autologous transforming growth factor-beta (TGF-beta)-resistant cytotoxic T-lymphocytes (CTL) reactive to human papilloma virus (HPV) types 16 and 18 E6/E7 antigens, with potential antineoplastic activity. Autologous T-lymphocytes from a HPV-positive cancer patient are exposed to and stimulated with dendritic cells (DCs) loaded with the HPV-16/18 proteins E6 and E7. In turn, the HPV-16/18 E6/E7-specific T-lymphocytes are transduced with a retroviral vector expressing a dominant-negative mutant of type II transforming growth factor (TGF)-beta receptor, which blocks signaling mediated by all three TGF-beta isoforms. Following re-administration to patients with HPV-positive tumors, the HPV-16/18 E6/E7-specific TGF-beta-resistant T lymphocytes target HPV16/18 E6/E7-positive cells, which may result in a specific cytotoxic T-lymphocyte (CTL) response, followed by cell lysis and the inhibition of tumor cell proliferation. Tumors expressing TGF-beta inhibit T-lymphocyte activation and expansion." @default.
- NCIT_C121537 NCIT_NHC0 "C121537" @default.
- NCIT_C121537 NCIT_P106 "Cell" @default.
- NCIT_C121537 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121537 NCIT_P108 "Autologous HPV-16/18 E6/E7-specific TGF-beta-resistant T Lymphocytes" @default.
- NCIT_C121537 NCIT_P207 "C4050617" @default.
- NCIT_C121537 NCIT_P329 "770039" @default.
- NCIT_C121537 NCIT_P330 "770039" @default.
- NCIT_C121537 NCIT_P399 "770039" @default.
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- NCIT_C121537 normalizedInformationContent "100" @default.
- NCIT_C121537 referenceCount "1" @default.
- NCIT_C121537 hasExactSynonym "Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes" @default.
- NCIT_C121537 hasExactSynonym "Autologous HPV-16/18 E6/E7-specific TGF-beta-resistant T Lymphocytes" @default.
- NCIT_C121537 hasExactSynonym "HPVST Cells" @default.
- NCIT_C121537 inSubset NCIT_C128784 @default.
- NCIT_C121537 inSubset NCIT_C176424 @default.
- NCIT_C121537 type Class @default.
- NCIT_C121537 isDefinedBy ncit.owl @default.
- NCIT_C121537 label "Autologous HPV-16/18 E6/E7-specific TGF-beta-resistant T Lymphocytes" @default.
- NCIT_C121537 subClassOf NCIT_C121537 @default.
- NCIT_C121537 subClassOf NCIT_C129820 @default.
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- NCIT_C121537 subClassOf NCIT_C274 @default.
- NCIT_C121537 subClassOf NCIT_C28681 @default.
- NCIT_C121537 subClassOf NCIT_C307 @default.
- NCIT_C121537 subClassOf NCIT_C308 @default.