Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C121539> ?p ?o ?g. }
Showing items 1 to 39 of
39
with 100 items per page.
- NCIT_C121539 IAO_0000115 "A nanoparticle-based formulation containing the poorly water-soluble, second-generation taxane analog docetaxel, with antineoplastic activity. Upon intravenous administration of the docetaxel-loaded nanopharmaceutical CRLX301, the nanoparticles are able to accumulate at the tumor site due to the unique characteristics of the tumor's vasculature, while avoiding normal, healthy tissue. In turn, CRLX301 is taken up by the tumor cell via macropinocytosis. Subsequently, docetaxel is slowly released into the cytoplasm where it binds to and stabilizes the beta-subunit of tubulin, thereby stabilizing microtubules and inhibiting microtubule disassembly. This prevents mitosis and results in cell death. Compared to the administration of docetaxel alone, this formulation is able to increase docetaxel's efficacy while avoiding systemic exposure, which minimizes its toxicity." @default.
- NCIT_C121539 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121539 NCIT_NHC0 "C121539" @default.
- NCIT_C121539 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121539 NCIT_P107 "Docetaxel-loaded Nanopharmaceutical CRLX301" @default.
- NCIT_C121539 NCIT_P108 "Docetaxel-loaded Nanopharmaceutical CRLX301" @default.
- NCIT_C121539 NCIT_P207 "C4053653" @default.
- NCIT_C121539 NCIT_P322 "CTRP" @default.
- NCIT_C121539 NCIT_P322 "GDC" @default.
- NCIT_C121539 NCIT_P329 "770081" @default.
- NCIT_C121539 NCIT_P330 "770081" @default.
- NCIT_C121539 NCIT_P375 "Docetaxel-loaded Nanopharmaceutical CRLX301" @default.
- NCIT_C121539 NCIT_P399 "770081" @default.
- NCIT_C121539 NCIT_R124 NCIT_C17828 @default.
- NCIT_C121539 NCIT_R124 NCIT_C20480 @default.
- NCIT_C121539 NCIT_R124 NCIT_C40795 @default.
- NCIT_C121539 NCIT_R124 NCIT_C40798 @default.
- NCIT_C121539 normalizedInformationContent "100" @default.
- NCIT_C121539 referenceCount "1" @default.
- NCIT_C121539 hasExactSynonym "CRLX301" @default.
- NCIT_C121539 hasExactSynonym "Docetaxel-loaded Nanopharmaceutical CRLX301" @default.
- NCIT_C121539 inSubset NCIT_C116977 @default.
- NCIT_C121539 inSubset NCIT_C116978 @default.
- NCIT_C121539 inSubset NCIT_C128784 @default.
- NCIT_C121539 inSubset NCIT_C157711 @default.
- NCIT_C121539 inSubset NCIT_C157712 @default.
- NCIT_C121539 inSubset NCIT_C176424 @default.
- NCIT_C121539 inSubset NCIT_C177537 @default.
- NCIT_C121539 type Class @default.
- NCIT_C121539 isDefinedBy ncit.owl @default.
- NCIT_C121539 label "Docetaxel-loaded Nanopharmaceutical CRLX301" @default.
- NCIT_C121539 subClassOf NCIT_C121539 @default.
- NCIT_C121539 subClassOf NCIT_C186664 @default.
- NCIT_C121539 subClassOf NCIT_C1908 @default.
- NCIT_C121539 subClassOf NCIT_C1909 @default.
- NCIT_C121539 subClassOf NCIT_C25974 @default.
- NCIT_C121539 subClassOf NCIT_C273 @default.
- NCIT_C121539 subClassOf NCIT_C274 @default.
- NCIT_C121539 subClassOf NCIT_C67437 @default.