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- NCIT_C121543 IAO_0000115 "An orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection. Upon oral administration, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. This prevents HIV-1 replication." @default.
- NCIT_C121543 NCIT_A5 NCIT_C148408 @default.
- NCIT_C121543 NCIT_NHC0 "C121543" @default.
- NCIT_C121543 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121543 NCIT_P107 "Dolutegravir" @default.
- NCIT_C121543 NCIT_P108 "Dolutegravir" @default.
- NCIT_C121543 NCIT_P207 "C3253985" @default.
- NCIT_C121543 NCIT_P210 "1051375-16-6" @default.
- NCIT_C121543 NCIT_P319 "DKO1W9H7M1" @default.
- NCIT_C121543 NCIT_P322 "CTRP" @default.
- NCIT_C121543 NCIT_P322 "FDA" @default.
- NCIT_C121543 NCIT_P329 "770209" @default.
- NCIT_C121543 NCIT_P330 "770209" @default.
- NCIT_C121543 NCIT_P399 "770209" @default.
- NCIT_C121543 normalizedInformationContent "100" @default.
- NCIT_C121543 referenceCount "1" @default.
- NCIT_C121543 hasExactSynonym "2H-Pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxamide, N-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)" @default.
- NCIT_C121543 hasExactSynonym "DOLUTEGRAVIR" @default.
- NCIT_C121543 hasExactSynonym "DTG" @default.
- NCIT_C121543 hasExactSynonym "Dolutegravir" @default.
- NCIT_C121543 hasExactSynonym "GSK 1349572" @default.
- NCIT_C121543 hasExactSynonym "GSK-1349572" @default.
- NCIT_C121543 inSubset NCIT_C116977 @default.
- NCIT_C121543 inSubset NCIT_C116978 @default.
- NCIT_C121543 inSubset NCIT_C176424 @default.
- NCIT_C121543 inSubset NCIT_C63923 @default.
- NCIT_C121543 type Class @default.
- NCIT_C121543 isDefinedBy ncit.owl @default.
- NCIT_C121543 label "Dolutegravir" @default.
- NCIT_C121543 subClassOf NCIT_C121543 @default.
- NCIT_C121543 subClassOf NCIT_C157401 @default.
- NCIT_C121543 subClassOf NCIT_C1660 @default.
- NCIT_C121543 subClassOf NCIT_C1908 @default.
- NCIT_C121543 subClassOf NCIT_C1909 @default.
- NCIT_C121543 subClassOf NCIT_C254 @default.
- NCIT_C121543 subClassOf NCIT_C281 @default.