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- NCIT_C121544 IAO_0000115 "A cancer vaccine comprised of a recombinant, attenuated, replication-defective simian adenovirus vector (ChAdOx1) encoding the human 5T4 fetal oncoprotein (ChAdOx1.5T4), with potential immuno-activating and antineoplastic activities. Upon administration of the recombinant attenuated chimpanzee adenovirus 5T4 vaccine, the viral vector expresses 5T4 and stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing 5T4, which results in tumor cell lysis. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types; its expression is correlated with increased invasiveness." @default.
- NCIT_C121544 NCIT_NHC0 "C121544" @default.
- NCIT_C121544 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C121544 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C121544 NCIT_P108 "Attenuated Chimpanzee Adenovirus 5T4 Vaccine" @default.
- NCIT_C121544 NCIT_P207 "C4055431" @default.
- NCIT_C121544 NCIT_P329 "770278" @default.
- NCIT_C121544 NCIT_P330 "770278" @default.
- NCIT_C121544 NCIT_P399 "770278" @default.
- NCIT_C121544 normalizedInformationContent "100" @default.
- NCIT_C121544 referenceCount "1" @default.
- NCIT_C121544 hasExactSynonym "Attenuated Chimpanzee Adenovirus 5T4 Vaccine" @default.
- NCIT_C121544 hasExactSynonym "ChAdOx.5T4 Vaccine" @default.
- NCIT_C121544 hasExactSynonym "ChAdOx1.5T4 Vaccine" @default.
- NCIT_C121544 inSubset NCIT_C128784 @default.
- NCIT_C121544 inSubset NCIT_C176424 @default.
- NCIT_C121544 type Class @default.
- NCIT_C121544 isDefinedBy ncit.owl @default.
- NCIT_C121544 label "Attenuated Chimpanzee Adenovirus 5T4 Vaccine" @default.
- NCIT_C121544 subClassOf NCIT_C121544 @default.
- NCIT_C121544 subClassOf NCIT_C1572 @default.
- NCIT_C121544 subClassOf NCIT_C1908 @default.
- NCIT_C121544 subClassOf NCIT_C1909 @default.
- NCIT_C121544 subClassOf NCIT_C307 @default.
- NCIT_C121544 subClassOf NCIT_C308 @default.
- NCIT_C121544 subClassOf NCIT_C49146 @default.
- NCIT_C121544 subClassOf NCIT_C923 @default.
- NCIT_C121544 subClassOf NCIT_C96404 @default.