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- NCIT_C121551 IAO_0000115 "An orally bioavailable radioconjugate composed of roniciclib, a cyclin dependent kinase (CDK) inhibitor, radiolabeled with carbon C 14, with potential use for evaluating the pharmacokinetic profile of roniciclib. Roniciclib selectively binds to and inhibits the activity of various CDK subtypes, which leads to cell cycle arrest and an inhibition of tumor cell proliferation. Labeling of roniciclib with the radioactive tracer carbon C 14 allows for the evaluation of roniciclib's pharmacokinetic profile, including its absorption, distribution, metabolism, and excretion (ADME). CDKs, serine/threonine kinases overexpressed in various tumor cell types, play key roles in the regulation of both cell cycle progression and cellular proliferation." @default.
- NCIT_C121551 NCIT_NHC0 "C121551" @default.
- NCIT_C121551 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121551 NCIT_P108 "Carbon C 14 Roniciclib" @default.
- NCIT_C121551 NCIT_P207 "C4055273" @default.
- NCIT_C121551 NCIT_P329 "770319" @default.
- NCIT_C121551 NCIT_P330 "770319" @default.
- NCIT_C121551 NCIT_P399 "770319" @default.
- NCIT_C121551 normalizedInformationContent "100" @default.
- NCIT_C121551 referenceCount "1" @default.
- NCIT_C121551 hasExactSynonym "Carbon C 14 Roniciclib" @default.
- NCIT_C121551 hasExactSynonym "[14C]-BAY1000394" @default.
- NCIT_C121551 hasExactSynonym "[14C]-roniciclib" @default.
- NCIT_C121551 inSubset NCIT_C176424 @default.
- NCIT_C121551 type Class @default.
- NCIT_C121551 isDefinedBy ncit.owl @default.
- NCIT_C121551 label "Carbon C 14 Roniciclib" @default.
- NCIT_C121551 subClassOf NCIT_C121551 @default.
- NCIT_C121551 subClassOf NCIT_C1446 @default.
- NCIT_C121551 subClassOf NCIT_C1908 @default.
- NCIT_C121551 subClassOf NCIT_C1909 @default.
- NCIT_C121551 subClassOf NCIT_C2124 @default.