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- NCIT_C121553 IAO_0000115 "An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Pemigatinib binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, migration, and survival." @default.
- NCIT_C121553 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121553 NCIT_A7 NCIT_C17297 @default.
- NCIT_C121553 NCIT_NHC0 "C121553" @default.
- NCIT_C121553 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121553 NCIT_P108 "Pemigatinib" @default.
- NCIT_C121553 NCIT_P207 "C4053633" @default.
- NCIT_C121553 NCIT_P210 "1513857-77-6" @default.
- NCIT_C121553 NCIT_P302 "for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement" @default.
- NCIT_C121553 NCIT_P319 "Y6BX7BL23K" @default.
- NCIT_C121553 NCIT_P322 "FDA" @default.
- NCIT_C121553 NCIT_P322 "GDC" @default.
- NCIT_C121553 NCIT_P329 "770381" @default.
- NCIT_C121553 NCIT_P330 "770381" @default.
- NCIT_C121553 NCIT_P375 "Pemigatinib" @default.
- NCIT_C121553 NCIT_P399 "770381" @default.
- NCIT_C121553 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C121553 referenceCount "2" @default.
- NCIT_C121553 hasExactSynonym "2H-Pyrrolo(3',2':5,6)pyrido(4,3-d)pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-" @default.
- NCIT_C121553 hasExactSynonym "INCB054828" @default.
- NCIT_C121553 hasExactSynonym "PEMIGATINIB" @default.
- NCIT_C121553 hasExactSynonym "Pemazyre" @default.
- NCIT_C121553 hasExactSynonym "Pemigatinib" @default.
- NCIT_C121553 inSubset NCIT_C128784 @default.
- NCIT_C121553 inSubset NCIT_C157711 @default.
- NCIT_C121553 inSubset NCIT_C157712 @default.
- NCIT_C121553 inSubset NCIT_C176424 @default.
- NCIT_C121553 inSubset NCIT_C177537 @default.
- NCIT_C121553 inSubset NCIT_C63923 @default.
- NCIT_C121553 type Class @default.
- NCIT_C121553 isDefinedBy ncit.owl @default.
- NCIT_C121553 label "Pemigatinib" @default.
- NCIT_C121553 subClassOf NCIT_C121553 @default.
- NCIT_C121553 subClassOf NCIT_C129824 @default.
- NCIT_C121553 subClassOf NCIT_C129825 @default.
- NCIT_C121553 subClassOf NCIT_C1404 @default.
- NCIT_C121553 subClassOf NCIT_C155727 @default.
- NCIT_C121553 subClassOf NCIT_C163758 @default.
- NCIT_C121553 subClassOf NCIT_C164035 @default.
- NCIT_C121553 subClassOf NCIT_C1908 @default.
- NCIT_C121553 subClassOf NCIT_C1909 @default.
- NCIT_C121553 subClassOf NCIT_C1967 @default.
- NCIT_C121553 subClassOf NCIT_C2189 @default.
- NCIT_C121553 subClassOf NCIT_C274 @default.
- NCIT_C121553 subClassOf NCIT_C471 @default.