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- NCIT_C121554 IAO_0000115 "A radiopharmaceutical citrate salt form of the positron-emitting radioisotope gallium Ga 68, with potential imaging activity upon positron emission tomography (PET). Upon administration of Gallium Ga 68 citrate, the gallium Ga 3+ ion dissociates from the weak citrate chelator. As Ga3+ is very similar to iron (Fe3+) in chemical properties, this ion acts as an iron analogue. Ga3+ binds to the iron-binding protein transferrin, distributes in blood, and enters and accumulates in the extracellular fluid space of inflamed or tumor-bearing tissue. In turn, the Ga3+-transferrin complex binds to transferrin receptors and is taken up by tumor cells. Tumor cells can then be imaged upon PET. Compared to healthy cells, tumor cells have increased iron metabolism and transferrin receptor expression. Increased Ga3+ uptake is seen in inflamed and infected tissues as well." @default.
- NCIT_C121554 NCIT_NHC0 "C121554" @default.
- NCIT_C121554 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C121554 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121554 NCIT_P107 "Gallium Ga 68 Citrate" @default.
- NCIT_C121554 NCIT_P108 "Gallium Ga 68 Citrate" @default.
- NCIT_C121554 NCIT_P207 "C3489514" @default.
- NCIT_C121554 NCIT_P210 "56578-07-5" @default.
- NCIT_C121554 NCIT_P319 "RD9L8XE13L" @default.
- NCIT_C121554 NCIT_P322 "CTRP" @default.
- NCIT_C121554 NCIT_P322 "FDA" @default.
- NCIT_C121554 NCIT_P329 "770382" @default.
- NCIT_C121554 NCIT_P330 "770382" @default.
- NCIT_C121554 NCIT_P399 "770382" @default.
- NCIT_C121554 normalizedInformationContent "100" @default.
- NCIT_C121554 referenceCount "1" @default.
- NCIT_C121554 hasExactSynonym "(68)Ga-citrate" @default.
- NCIT_C121554 hasExactSynonym "68Ga-Citrate" @default.
- NCIT_C121554 hasExactSynonym "GALLIUM CITRATE GA-68" @default.
- NCIT_C121554 hasExactSynonym "Gallium Ga 68 Citrate" @default.
- NCIT_C121554 hasExactSynonym "Gallium-68 Citrate" @default.
- NCIT_C121554 inSubset NCIT_C116977 @default.
- NCIT_C121554 inSubset NCIT_C116978 @default.
- NCIT_C121554 inSubset NCIT_C176424 @default.
- NCIT_C121554 inSubset NCIT_C63923 @default.
- NCIT_C121554 type Class @default.
- NCIT_C121554 isDefinedBy ncit.owl @default.
- NCIT_C121554 label "Gallium Ga 68 Citrate" @default.
- NCIT_C121554 subClassOf NCIT_C121554 @default.
- NCIT_C121554 subClassOf NCIT_C1908 @default.
- NCIT_C121554 subClassOf NCIT_C1913 @default.
- NCIT_C121554 subClassOf NCIT_C1940 @default.
- NCIT_C121554 subClassOf NCIT_C47933 @default.
- NCIT_C121554 subClassOf NCIT_C579 @default.
- NCIT_C121554 subClassOf NCIT_C799 @default.