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- NCIT_C121569 IAO_0000115 "An orally available combination formulation containing netupitant, a selective neurokinin 1 (NK1) receptor antagonist, and the hydrochloride salt form of palonosetron, a selective serotonin (5-hydroxytryptamine; 5-HT) receptor subtype 3 (5-HT3) antagonist, with antiemetic activity. Upon oral administration, palonosetron competitively blocks the action of 5-HT at 5-HT3 receptors located on vagal afferent nerves in the chemoreceptor trigger zone (CTZ). This inhibits acute emesis associated with 5-HT secretion and subsequent 5-HT3 activation. Netupitant competitively binds to and blocks the activity of the human NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1 receptor binding of the endogenous tachykinin neuropeptide substance P (SP). This prevents delayed emesis, which is associated with SP secretion. Altogether, this results in the prevention of chemotherapy-induced nausea and vomiting (CINV)." @default.
- NCIT_C121569 NCIT_NHC0 "C121569" @default.
- NCIT_C121569 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121569 NCIT_P107 "Netupitant/Palonosetron Hydrochloride" @default.
- NCIT_C121569 NCIT_P108 "Netupitant/Palonosetron Hydrochloride" @default.
- NCIT_C121569 NCIT_P207 "C3858030" @default.
- NCIT_C121569 NCIT_P322 "CTRP" @default.
- NCIT_C121569 NCIT_P329 "771103" @default.
- NCIT_C121569 NCIT_P330 "771103" @default.
- NCIT_C121569 NCIT_P399 "771103" @default.
- NCIT_C121569 normalizedInformationContent "100" @default.
- NCIT_C121569 referenceCount "1" @default.
- NCIT_C121569 hasExactSynonym "Akynzeo" @default.
- NCIT_C121569 hasExactSynonym "Netupitant and Palonosetron" @default.
- NCIT_C121569 hasExactSynonym "Netupitant/Palonosetron Hydrochloride" @default.
- NCIT_C121569 hasExactSynonym "Netupitant/Palonosetron" @default.
- NCIT_C121569 inSubset NCIT_C116977 @default.
- NCIT_C121569 inSubset NCIT_C116978 @default.
- NCIT_C121569 inSubset NCIT_C176424 @default.
- NCIT_C121569 type Class @default.
- NCIT_C121569 isDefinedBy ncit.owl @default.
- NCIT_C121569 label "Netupitant/Palonosetron Hydrochloride" @default.
- NCIT_C121569 subClassOf NCIT_C121569 @default.
- NCIT_C121569 subClassOf NCIT_C1908 @default.
- NCIT_C121569 subClassOf NCIT_C1909 @default.
- NCIT_C121569 subClassOf NCIT_C267 @default.
- NCIT_C121569 subClassOf NCIT_C78272 @default.