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- NCIT_C121570 IAO_0000115 "A multi-antigen DNA vaccine consisting of plasmids encoding the hepatitis C virus (HCV) nonstructural proteins 3 (NS3), 4A (NS4A), 4B (NS4B) and 5A (NS5A), with potential immunomodulating and cancer preventive activities. Administered via intramuscular injection followed by electroporation, cells transfected with the HCV DNA vaccine INO-8000 express the encoded HCV proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response against HCV-infected liver cells expressing the NS3, NS4A, NS4B or NS5A proteins. This results in the eradication of HCV-infected cells. HCV, a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family, is associated with the development of hepatocellular carcinoma (HCC)." @default.
- NCIT_C121570 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121570 NCIT_NHC0 "C121570" @default.
- NCIT_C121570 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121570 NCIT_P107 "HCV DNA Vaccine INO-8000" @default.
- NCIT_C121570 NCIT_P108 "HCV DNA Vaccine INO-8000" @default.
- NCIT_C121570 NCIT_P207 "C4053630" @default.
- NCIT_C121570 NCIT_P322 "CTRP" @default.
- NCIT_C121570 NCIT_P322 "GDC" @default.
- NCIT_C121570 NCIT_P329 "771488" @default.
- NCIT_C121570 NCIT_P330 "771488" @default.
- NCIT_C121570 NCIT_P375 "HCV DNA Vaccine INO-8000" @default.
- NCIT_C121570 NCIT_P399 "771488" @default.
- NCIT_C121570 normalizedInformationContent "100" @default.
- NCIT_C121570 referenceCount "1" @default.
- NCIT_C121570 hasExactSynonym "HCV DNA Vaccine INO-8000" @default.
- NCIT_C121570 hasExactSynonym "INO-8000" @default.
- NCIT_C121570 inSubset NCIT_C116977 @default.
- NCIT_C121570 inSubset NCIT_C116978 @default.
- NCIT_C121570 inSubset NCIT_C128784 @default.
- NCIT_C121570 inSubset NCIT_C157711 @default.
- NCIT_C121570 inSubset NCIT_C157712 @default.
- NCIT_C121570 inSubset NCIT_C176424 @default.
- NCIT_C121570 inSubset NCIT_C177537 @default.
- NCIT_C121570 type Class @default.
- NCIT_C121570 isDefinedBy ncit.owl @default.
- NCIT_C121570 label "HCV DNA Vaccine INO-8000" @default.
- NCIT_C121570 subClassOf NCIT_C121570 @default.
- NCIT_C121570 subClassOf NCIT_C129820 @default.
- NCIT_C121570 subClassOf NCIT_C1663 @default.
- NCIT_C121570 subClassOf NCIT_C1908 @default.
- NCIT_C121570 subClassOf NCIT_C1909 @default.
- NCIT_C121570 subClassOf NCIT_C274 @default.
- NCIT_C121570 subClassOf NCIT_C307 @default.
- NCIT_C121570 subClassOf NCIT_C308 @default.
- NCIT_C121570 subClassOf NCIT_C39619 @default.
- NCIT_C121570 subClassOf NCIT_C923 @default.