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- NCIT_C121639 IAO_0000115 "An orally available selective inhibitor of the histone lysine methyltransferase EZH2, with potential antineoplastic activity. Upon oral administration, lirametostat selectively inhibits the activity of both wild-type and mutated forms of EZH2. Inhibition of EZH2 specifically prevents the methylation of histone H3 on lysine 27 (H3K27). This decrease in histone methylation alters gene expression patterns associated with cancer pathways and results in decreased proliferation of EZH2-expressing cancer cells. EZH2, a histone lysine methyltransferase (HMT) class enzyme and the catalytic subunit of the polycomb repressive complex 2 (PRC2), is overexpressed or mutated in a variety of cancer cells and plays a key role in tumor cell proliferation; its expression is correlated with tumor initiation, progression, stem cell self-renewal, migration and angiogenesis." @default.
- NCIT_C121639 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121639 NCIT_A7 NCIT_C30175 @default.
- NCIT_C121639 NCIT_NHC0 "C121639" @default.
- NCIT_C121639 NCIT_P106 "Organic Chemical" @default.
- NCIT_C121639 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121639 NCIT_P107 "Lirametostat" @default.
- NCIT_C121639 NCIT_P108 "Lirametostat" @default.
- NCIT_C121639 NCIT_P207 "C4053654" @default.
- NCIT_C121639 NCIT_P210 "1621862-70-1" @default.
- NCIT_C121639 NCIT_P319 "455J2479FY" @default.
- NCIT_C121639 NCIT_P322 "CTRP" @default.
- NCIT_C121639 NCIT_P322 "FDA" @default.
- NCIT_C121639 NCIT_P322 "GDC" @default.
- NCIT_C121639 NCIT_P329 "770459" @default.
- NCIT_C121639 NCIT_P330 "770459" @default.
- NCIT_C121639 NCIT_P375 "EZH2 Inhibitor CPI-1205" @default.
- NCIT_C121639 NCIT_P399 "770459" @default.
- NCIT_C121639 normalizedInformationContent "100" @default.
- NCIT_C121639 referenceCount "1" @default.
- NCIT_C121639 hasExactSynonym "CPI-1205" @default.
- NCIT_C121639 hasExactSynonym "EZH2 Inhibitor CPI-1205" @default.
- NCIT_C121639 hasExactSynonym "LIRAMETOSTAT" @default.
- NCIT_C121639 hasExactSynonym "Lirametostat" @default.
- NCIT_C121639 inSubset NCIT_C116977 @default.
- NCIT_C121639 inSubset NCIT_C116978 @default.
- NCIT_C121639 inSubset NCIT_C128784 @default.
- NCIT_C121639 inSubset NCIT_C157711 @default.
- NCIT_C121639 inSubset NCIT_C157712 @default.
- NCIT_C121639 inSubset NCIT_C176424 @default.
- NCIT_C121639 inSubset NCIT_C177537 @default.
- NCIT_C121639 inSubset NCIT_C63923 @default.
- NCIT_C121639 type Class @default.
- NCIT_C121639 isDefinedBy ncit.owl @default.
- NCIT_C121639 label "Lirametostat" @default.
- NCIT_C121639 subClassOf NCIT_C121639 @default.
- NCIT_C121639 subClassOf NCIT_C129824 @default.
- NCIT_C121639 subClassOf NCIT_C129825 @default.
- NCIT_C121639 subClassOf NCIT_C156804 @default.
- NCIT_C121639 subClassOf NCIT_C1908 @default.
- NCIT_C121639 subClassOf NCIT_C1909 @default.
- NCIT_C121639 subClassOf NCIT_C2189 @default.
- NCIT_C121639 subClassOf NCIT_C274 @default.
- NCIT_C121639 subClassOf NCIT_C471 @default.