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- NCIT_C121641 IAO_0000115 "An orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, citarinostat inhibits the activity of HDACs; this results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes, which inhibit tumor cell division and induce tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins." @default.
- NCIT_C121641 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121641 NCIT_A7 NCIT_C16682 @default.
- NCIT_C121641 NCIT_NHC0 "C121641" @default.
- NCIT_C121641 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121641 NCIT_P107 "Citarinostat" @default.
- NCIT_C121641 NCIT_P108 "Citarinostat" @default.
- NCIT_C121641 NCIT_P207 "C4053685" @default.
- NCIT_C121641 NCIT_P210 "1316215-12-9" @default.
- NCIT_C121641 NCIT_P319 "441P620G3P" @default.
- NCIT_C121641 NCIT_P322 "CTRP" @default.
- NCIT_C121641 NCIT_P322 "FDA" @default.
- NCIT_C121641 NCIT_P322 "GDC" @default.
- NCIT_C121641 NCIT_P329 "770662" @default.
- NCIT_C121641 NCIT_P330 "770662" @default.
- NCIT_C121641 NCIT_P375 "Citarinostat" @default.
- NCIT_C121641 NCIT_P399 "770662" @default.
- NCIT_C121641 normalizedInformationContent "100" @default.
- NCIT_C121641 referenceCount "1" @default.
- NCIT_C121641 hasExactSynonym "2-((2-Chlorophenyl)phenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-5-pyrimidinecarboxamide" @default.
- NCIT_C121641 hasExactSynonym "5-Pyrimidinecarboxamide, 2-((2-Chlorophenyl)phenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-" @default.
- NCIT_C121641 hasExactSynonym "ACY-241" @default.
- NCIT_C121641 hasExactSynonym "CC-96241" @default.
- NCIT_C121641 hasExactSynonym "CITARINOSTAT" @default.
- NCIT_C121641 hasExactSynonym "Citarinostat" @default.
- NCIT_C121641 hasExactSynonym "HDAC-IN-2" @default.
- NCIT_C121641 hasExactSynonym "Histone Deacetylase Inhibitor ACY-241" @default.
- NCIT_C121641 inSubset NCIT_C116977 @default.
- NCIT_C121641 inSubset NCIT_C116978 @default.
- NCIT_C121641 inSubset NCIT_C128784 @default.
- NCIT_C121641 inSubset NCIT_C157711 @default.
- NCIT_C121641 inSubset NCIT_C157712 @default.
- NCIT_C121641 inSubset NCIT_C176424 @default.
- NCIT_C121641 inSubset NCIT_C177537 @default.
- NCIT_C121641 inSubset NCIT_C63923 @default.
- NCIT_C121641 type Class @default.
- NCIT_C121641 isDefinedBy ncit.owl @default.
- NCIT_C121641 label "Citarinostat" @default.
- NCIT_C121641 subClassOf NCIT_C121641 @default.
- NCIT_C121641 subClassOf NCIT_C129824 @default.
- NCIT_C121641 subClassOf NCIT_C129825 @default.
- NCIT_C121641 subClassOf NCIT_C163758 @default.
- NCIT_C121641 subClassOf NCIT_C1908 @default.
- NCIT_C121641 subClassOf NCIT_C1909 @default.
- NCIT_C121641 subClassOf NCIT_C1946 @default.
- NCIT_C121641 subClassOf NCIT_C2189 @default.
- NCIT_C121641 subClassOf NCIT_C274 @default.
- NCIT_C121641 subClassOf NCIT_C471 @default.