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- NCIT_C121653 IAO_0000115 "An anti-mesothelin (MSLN) recombinant cytolytic fusion protein (cFP) composed of a humanized Fab fragment of anti-MSLN monoclonal antibody SS1 linked to a truncated and de-immunized 24 kDa fragment of the Pseudomonas exotoxin (PE) (PE24), with potential antineoplastic activity. Upon intravenous administration of anti-MSLN-PE24 cFP LMB-100, the anti-MSLN moiety targets and binds to MSLN-expressing tumor cells. Upon binding and internalization through endocytosis, the toxin moiety ADP-ribosylates and inactivates eukaryotic elongation factor 2 (eEF2), preventing the elongation step of protein synthesis and leading to both an inhibition of protein synthesis and an induction of MSLN-expressing tumor cell apoptosis. MSLN, a tumor-associated antigen overexpressed in a variety of cancer cell types, plays a key role in tumor cell proliferation and migration. The engineered PE24 portion of LMB-100 does contain the targeting domain and furin cleavage site, which are needed for cytotoxicity, but most of the translocation domain II is deleted and the catalytic domain III contains point mutations, which result in the deletion and silencing of most T- and B-cell epitopes; therefore, the immunogenicity and toxicity is reduced compared to non-engineered PE toxin, which allows for the administration of larger doses of LMB-100." @default.
- NCIT_C121653 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121653 NCIT_A7 NCIT_C20887 @default.
- NCIT_C121653 NCIT_NHC0 "C121653" @default.
- NCIT_C121653 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121653 NCIT_P107 "Anti-mesothelin-Pseudomonas Exotoxin 24 Cytolytic Fusion Protein LMB-100" @default.
- NCIT_C121653 NCIT_P108 "Anti-mesothelin-Pseudomonas Exotoxin 24 Cytolytic Fusion Protein LMB-100" @default.
- NCIT_C121653 NCIT_P207 "C4044528" @default.
- NCIT_C121653 NCIT_P210 "1841500-93-3" @default.
- NCIT_C121653 NCIT_P319 "D6AT024T4P" @default.
- NCIT_C121653 NCIT_P322 "CTRP" @default.
- NCIT_C121653 NCIT_P322 "FDA" @default.
- NCIT_C121653 NCIT_P322 "GDC" @default.
- NCIT_C121653 NCIT_P329 "767396" @default.
- NCIT_C121653 NCIT_P330 "767396" @default.
- NCIT_C121653 NCIT_P375 "Anti-mesothelin-Pseudomonas Exotoxin 24 Cytolytic Fusion Protein LMB-100" @default.
- NCIT_C121653 NCIT_P399 "767396" @default.
- NCIT_C121653 normalizedInformationContent "100" @default.
- NCIT_C121653 referenceCount "1" @default.
- NCIT_C121653 hasExactSynonym "Anti-MSLN-PE24 cFP LMB-100" @default.
- NCIT_C121653 hasExactSynonym "Anti-mesothelin-Pseudomonas Exotoxin 24 Cytolytic Fusion Protein LMB-100" @default.
- NCIT_C121653 hasExactSynonym "LMB-100" @default.
- NCIT_C121653 hasExactSynonym "RG 7787" @default.
- NCIT_C121653 hasExactSynonym "RG-7787" @default.
- NCIT_C121653 hasExactSynonym "RG7787" @default.
- NCIT_C121653 hasExactSynonym "RO 6927005" @default.
- NCIT_C121653 hasExactSynonym "RO6927005" @default.
- NCIT_C121653 inSubset NCIT_C116977 @default.
- NCIT_C121653 inSubset NCIT_C116978 @default.
- NCIT_C121653 inSubset NCIT_C128784 @default.
- NCIT_C121653 inSubset NCIT_C157711 @default.
- NCIT_C121653 inSubset NCIT_C157712 @default.
- NCIT_C121653 inSubset NCIT_C176424 @default.
- NCIT_C121653 inSubset NCIT_C177537 @default.
- NCIT_C121653 inSubset NCIT_C63923 @default.
- NCIT_C121653 type Class @default.
- NCIT_C121653 isDefinedBy ncit.owl @default.
- NCIT_C121653 label "Anti-mesothelin-Pseudomonas Exotoxin 24 Cytolytic Fusion Protein LMB-100" @default.
- NCIT_C121653 subClassOf NCIT_C121653 @default.
- NCIT_C121653 subClassOf NCIT_C1512 @default.
- NCIT_C121653 subClassOf NCIT_C1908 @default.
- NCIT_C121653 subClassOf NCIT_C1909 @default.
- NCIT_C121653 subClassOf NCIT_C307 @default.
- NCIT_C121653 subClassOf NCIT_C308 @default.