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- NCIT_C121775 IAO_0000115 "A monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, tislelizumab binds to PD-1 and inhibits the binding of PD-1 to the PD-1 ligands programmed cell death-1 ligand 1 (PD-L1), and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of both T-cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin (Ig) superfamily expressed on activated T-cells, negatively regulates T-cell activation and effector function when activated by its ligands; it plays an important role in tumor evasion from host immunity." @default.
- NCIT_C121775 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121775 NCIT_A7 NCIT_C94697 @default.
- NCIT_C121775 NCIT_NHC0 "C121775" @default.
- NCIT_C121775 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C121775 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C121775 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121775 NCIT_P107 "Tislelizumab" @default.
- NCIT_C121775 NCIT_P108 "Tislelizumab" @default.
- NCIT_C121775 NCIT_P207 "C4053664" @default.
- NCIT_C121775 NCIT_P210 "1858168-59-8" @default.
- NCIT_C121775 NCIT_P319 "0KVO411B3N" @default.
- NCIT_C121775 NCIT_P322 "CTRP" @default.
- NCIT_C121775 NCIT_P322 "FDA" @default.
- NCIT_C121775 NCIT_P322 "GDC" @default.
- NCIT_C121775 NCIT_P329 "770893" @default.
- NCIT_C121775 NCIT_P330 "770893" @default.
- NCIT_C121775 NCIT_P375 "Tislelizumab" @default.
- NCIT_C121775 NCIT_P399 "770893" @default.
- NCIT_C121775 NCIT_R124 NCIT_C17710 @default.
- NCIT_C121775 NCIT_R124 NCIT_C17828 @default.
- NCIT_C121775 NCIT_R124 NCIT_C18219 @default.
- NCIT_C121775 NCIT_R124 NCIT_C19986 @default.
- NCIT_C121775 NCIT_R124 NCIT_C40474 @default.
- NCIT_C121775 normalizedInformationContent "100" @default.
- NCIT_C121775 referenceCount "1" @default.
- NCIT_C121775 hasExactSynonym "BGB-A317" @default.
- NCIT_C121775 hasExactSynonym "TISLELIZUMAB" @default.
- NCIT_C121775 hasExactSynonym "Tirelizumab" @default.
- NCIT_C121775 hasExactSynonym "Tislelizumab" @default.
- NCIT_C121775 inSubset NCIT_C116977 @default.
- NCIT_C121775 inSubset NCIT_C116978 @default.
- NCIT_C121775 inSubset NCIT_C128784 @default.
- NCIT_C121775 inSubset NCIT_C157711 @default.
- NCIT_C121775 inSubset NCIT_C157712 @default.
- NCIT_C121775 inSubset NCIT_C176424 @default.
- NCIT_C121775 inSubset NCIT_C177537 @default.
- NCIT_C121775 inSubset NCIT_C63923 @default.
- NCIT_C121775 type Class @default.
- NCIT_C121775 isDefinedBy ncit.owl @default.
- NCIT_C121775 label "Tislelizumab" @default.
- NCIT_C121775 subClassOf NCIT_C121775 @default.
- NCIT_C121775 subClassOf NCIT_C124946 @default.
- NCIT_C121775 subClassOf NCIT_C128037 @default.
- NCIT_C121775 subClassOf NCIT_C129821 @default.
- NCIT_C121775 subClassOf NCIT_C129822 @default.
- NCIT_C121775 subClassOf NCIT_C141144 @default.
- NCIT_C121775 subClassOf NCIT_C143250 @default.
- NCIT_C121775 subClassOf NCIT_C163758 @default.
- NCIT_C121775 subClassOf NCIT_C1908 @default.
- NCIT_C121775 subClassOf NCIT_C1909 @default.
- NCIT_C121775 subClassOf NCIT_C20401 @default.
- NCIT_C121775 subClassOf NCIT_C274 @default.
- NCIT_C121775 subClassOf NCIT_C307 @default.
- NCIT_C121775 subClassOf NCIT_C308 @default.