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- NCIT_C121777 IAO_0000115 "A cancer vaccine containing pTVG4 plasmid DNA encoding the human androgen receptor (AR) ligand-binding domain (LBD) (pTVG-AR), with potential immunostimulating and antineoplastic activities. Upon intradermal administration of AR LBD-encoding plasmid DNA vaccine MVI-118, the plasmid DNA vaccine expresses AR LBD and may stimulate the host immune system to generate a cytotoxic T-lymphocyte (CTL) response against AR LBD-expressing prostate cancer cells. This reduces proliferation of AR-expressing tumor cells. AR, a tumor-associated antigen (TAA) overexpressed in prostate cancer cells, plays a key role in the development and progression of prostate cancer; its expression is correlated with poor prognosis." @default.
- NCIT_C121777 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121777 NCIT_NHC0 "C121777" @default.
- NCIT_C121777 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121777 NCIT_P108 "Androgen Receptor Ligand-binding Domain-encoding Plasmid DNA Vaccine MVI-118" @default.
- NCIT_C121777 NCIT_P207 "C4053487" @default.
- NCIT_C121777 NCIT_P322 "GDC" @default.
- NCIT_C121777 NCIT_P329 "771098" @default.
- NCIT_C121777 NCIT_P330 "771098" @default.
- NCIT_C121777 NCIT_P375 "Androgen Receptor Ligand-binding Domain-encoding Plasmid DNA Vaccine MVI-118" @default.
- NCIT_C121777 NCIT_P399 "771098" @default.
- NCIT_C121777 normalizedInformationContent "100" @default.
- NCIT_C121777 referenceCount "1" @default.
- NCIT_C121777 hasExactSynonym "AR LBD-encoding Plasmid DNA Vaccine MVI-118" @default.
- NCIT_C121777 hasExactSynonym "Androgen Receptor Ligand-binding Domain-encoding Plasmid DNA Vaccine MVI-118" @default.
- NCIT_C121777 hasExactSynonym "MVI-118" @default.
- NCIT_C121777 hasExactSynonym "pTVG-AR Vaccine" @default.
- NCIT_C121777 hasExactSynonym "pTVG-AR" @default.
- NCIT_C121777 inSubset NCIT_C128784 @default.
- NCIT_C121777 inSubset NCIT_C157711 @default.
- NCIT_C121777 inSubset NCIT_C157712 @default.
- NCIT_C121777 inSubset NCIT_C176424 @default.
- NCIT_C121777 inSubset NCIT_C177537 @default.
- NCIT_C121777 type Class @default.
- NCIT_C121777 isDefinedBy ncit.owl @default.
- NCIT_C121777 label "Androgen Receptor Ligand-binding Domain-encoding Plasmid DNA Vaccine MVI-118" @default.
- NCIT_C121777 subClassOf NCIT_C121777 @default.
- NCIT_C121777 subClassOf NCIT_C129820 @default.
- NCIT_C121777 subClassOf NCIT_C1663 @default.
- NCIT_C121777 subClassOf NCIT_C1908 @default.
- NCIT_C121777 subClassOf NCIT_C1909 @default.
- NCIT_C121777 subClassOf NCIT_C274 @default.
- NCIT_C121777 subClassOf NCIT_C307 @default.
- NCIT_C121777 subClassOf NCIT_C308 @default.
- NCIT_C121777 subClassOf NCIT_C39619 @default.
- NCIT_C121777 subClassOf NCIT_C923 @default.