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- NCIT_C121817 IAO_0000115 "An orally bioavailable, small molecule inhibitor of certain class I phosphoinositide 3-kinase (PI3K) isoforms and mammalian target of rapamycin kinase (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Samotolisib inhibits both certain PI3K isoforms and mTOR in an ATP-competitive manner which may inhibit both the PI3K/mTOR signaling pathway in and proliferation of tumor cells overexpressing PI3K and/or mTOR. The PI3K/mTOR pathway is upregulated in a variety of tumor cells and plays a key role in promoting cancer cell proliferation, and survival, motility and resistance to chemotherapy and radiotherapy. mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion; therefore, this agent may be more potent than an agent that inhibits either PI3K or mTOR alone. In addition, LY3023414 may inhibit DNA-dependent protein kinase (DNA-PK), thereby inhibiting the ability of tumor cells to repair damaged DNA. DNA-PK is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks." @default.
- NCIT_C121817 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121817 NCIT_A7 NCIT_C17270 @default.
- NCIT_C121817 NCIT_A7 NCIT_C38929 @default.
- NCIT_C121817 NCIT_NHC0 "C121817" @default.
- NCIT_C121817 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121817 NCIT_P107 "Samotolisib" @default.
- NCIT_C121817 NCIT_P108 "Samotolisib" @default.
- NCIT_C121817 NCIT_P208 "CL446628" @default.
- NCIT_C121817 NCIT_P210 "1386874-06-1" @default.
- NCIT_C121817 NCIT_P319 "C88817F47Y" @default.
- NCIT_C121817 NCIT_P322 "CTRP" @default.
- NCIT_C121817 NCIT_P322 "FDA" @default.
- NCIT_C121817 NCIT_P322 "GDC" @default.
- NCIT_C121817 NCIT_P329 "738090" @default.
- NCIT_C121817 NCIT_P330 "738090" @default.
- NCIT_C121817 NCIT_P375 "Samotolisib" @default.
- NCIT_C121817 NCIT_P399 "738090" @default.
- NCIT_C121817 normalizedInformationContent "100" @default.
- NCIT_C121817 referenceCount "1" @default.
- NCIT_C121817 hasExactSynonym "2H-Imidazo(4,5-C)quinolin-2-one, 1,3-Dihydro-8-(5-(1-hydroxy-1-methylethyl)-3-pyridinyl)-1-((2S)-2-methoxypropyl)-3-methyl-" @default.
- NCIT_C121817 hasExactSynonym "LY 3023414" @default.
- NCIT_C121817 hasExactSynonym "LY-3023414" @default.
- NCIT_C121817 hasExactSynonym "LY3023414" @default.
- NCIT_C121817 hasExactSynonym "PI3K/mTOR Inhibitor LY3023414" @default.
- NCIT_C121817 hasExactSynonym "SAMOTOLISIB" @default.
- NCIT_C121817 hasExactSynonym "Samotolisib" @default.
- NCIT_C121817 hasExactSynonym "WHO 10889" @default.
- NCIT_C121817 inSubset NCIT_C116977 @default.
- NCIT_C121817 inSubset NCIT_C116978 @default.
- NCIT_C121817 inSubset NCIT_C128784 @default.
- NCIT_C121817 inSubset NCIT_C157711 @default.
- NCIT_C121817 inSubset NCIT_C157712 @default.
- NCIT_C121817 inSubset NCIT_C176424 @default.
- NCIT_C121817 inSubset NCIT_C177537 @default.
- NCIT_C121817 inSubset NCIT_C63923 @default.
- NCIT_C121817 type Class @default.
- NCIT_C121817 isDefinedBy ncit.owl @default.
- NCIT_C121817 label "Samotolisib" @default.
- NCIT_C121817 subClassOf NCIT_C121817 @default.
- NCIT_C121817 subClassOf NCIT_C129824 @default.
- NCIT_C121817 subClassOf NCIT_C129825 @default.
- NCIT_C121817 subClassOf NCIT_C1404 @default.
- NCIT_C121817 subClassOf NCIT_C163758 @default.
- NCIT_C121817 subClassOf NCIT_C1742 @default.
- NCIT_C121817 subClassOf NCIT_C1908 @default.
- NCIT_C121817 subClassOf NCIT_C1909 @default.
- NCIT_C121817 subClassOf NCIT_C192218 @default.
- NCIT_C121817 subClassOf NCIT_C2152 @default.
- NCIT_C121817 subClassOf NCIT_C2189 @default.
- NCIT_C121817 subClassOf NCIT_C2201 @default.
- NCIT_C121817 subClassOf NCIT_C274 @default.
- NCIT_C121817 subClassOf NCIT_C471 @default.
- NCIT_C121817 subClassOf NCIT_C61074 @default.