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- NCIT_C121828 IAO_0000115 "An orally bioavailable 4-thio modified 2-deoxycytidine analog, with potential antineoplastic activity. Upon administration of 4-thio-2-deoxycytidine (TdCyd), this cytidine analog gets incorporated into DNA during replication and inhibits the activity of DNA methyltransferase 1 (DNMT1), which blocks DNA hypermethylation. This results in DNMT1 depletion, hypomethylation of DNA, and the reactivation of tumor suppressor genes that were silenced by hypermethylation; this results in antitumor activity and an inhibition of tumor cell proliferation." @default.
- NCIT_C121828 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121828 NCIT_NHC0 "C121828" @default.
- NCIT_C121828 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C121828 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121828 NCIT_P107 "4-Thio-2-deoxycytidine" @default.
- NCIT_C121828 NCIT_P108 "4-Thio-2-deoxycytidine" @default.
- NCIT_C121828 NCIT_P207 "C0647434" @default.
- NCIT_C121828 NCIT_P210 "134111-30-1" @default.
- NCIT_C121828 NCIT_P319 "L76O0M313F" @default.
- NCIT_C121828 NCIT_P322 "CTRP" @default.
- NCIT_C121828 NCIT_P322 "FDA" @default.
- NCIT_C121828 NCIT_P322 "GDC" @default.
- NCIT_C121828 NCIT_P329 "771603" @default.
- NCIT_C121828 NCIT_P330 "771603" @default.
- NCIT_C121828 NCIT_P375 "4-Thio-2-deoxycytidine" @default.
- NCIT_C121828 NCIT_P399 "771603" @default.
- NCIT_C121828 normalizedInformationContent "100" @default.
- NCIT_C121828 referenceCount "1" @default.
- NCIT_C121828 hasExactSynonym "4'-THIO-2'-DEOXYCYTIDINE" @default.
- NCIT_C121828 hasExactSynonym "4'-Thio-2'-deoxycytidine" @default.
- NCIT_C121828 hasExactSynonym "4-Thio-2-deoxycytidine" @default.
- NCIT_C121828 hasExactSynonym "T-dCyd" @default.
- NCIT_C121828 hasExactSynonym "TdCyd" @default.
- NCIT_C121828 inSubset NCIT_C116977 @default.
- NCIT_C121828 inSubset NCIT_C116978 @default.
- NCIT_C121828 inSubset NCIT_C128784 @default.
- NCIT_C121828 inSubset NCIT_C157711 @default.
- NCIT_C121828 inSubset NCIT_C157712 @default.
- NCIT_C121828 inSubset NCIT_C176424 @default.
- NCIT_C121828 inSubset NCIT_C177537 @default.
- NCIT_C121828 inSubset NCIT_C63923 @default.
- NCIT_C121828 type Class @default.
- NCIT_C121828 isDefinedBy ncit.owl @default.
- NCIT_C121828 label "4-Thio-2-deoxycytidine" @default.
- NCIT_C121828 subClassOf NCIT_C121828 @default.
- NCIT_C121828 subClassOf NCIT_C1557 @default.
- NCIT_C121828 subClassOf NCIT_C186664 @default.
- NCIT_C121828 subClassOf NCIT_C1908 @default.
- NCIT_C121828 subClassOf NCIT_C1909 @default.
- NCIT_C121828 subClassOf NCIT_C272 @default.
- NCIT_C121828 subClassOf NCIT_C274 @default.