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- NCIT_C121849 IAO_0000115 "An inhibitor of the Bromodomain (BRD) and Extra-Terminal domain (BET) family of proteins, with potential antineoplastic activity. Upon administration, the BET inhibitor BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth. BET proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional regulators that bind to acetylated lysines on the tails of histones H3 and H4, and regulate chromatin structure and function; they play an important role in the modulation of gene expression during development and cellular growth." @default.
- NCIT_C121849 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121849 NCIT_A7 NCIT_C106463 @default.
- NCIT_C121849 NCIT_A7 NCIT_C21376 @default.
- NCIT_C121849 NCIT_A7 NCIT_C92704 @default.
- NCIT_C121849 NCIT_A7 NCIT_C97399 @default.
- NCIT_C121849 NCIT_NHC0 "C121849" @default.
- NCIT_C121849 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121849 NCIT_P107 "BET Inhibitor BMS-986158" @default.
- NCIT_C121849 NCIT_P108 "BET Inhibitor BMS-986158" @default.
- NCIT_C121849 NCIT_P207 "C4053659" @default.
- NCIT_C121849 NCIT_P210 "1800340-40-2" @default.
- NCIT_C121849 NCIT_P319 "X8BW0MQ5PI" @default.
- NCIT_C121849 NCIT_P322 "CTRP" @default.
- NCIT_C121849 NCIT_P322 "FDA" @default.
- NCIT_C121849 NCIT_P322 "GDC" @default.
- NCIT_C121849 NCIT_P329 "771520" @default.
- NCIT_C121849 NCIT_P330 "771520" @default.
- NCIT_C121849 NCIT_P375 "BET Inhibitor BMS-986158" @default.
- NCIT_C121849 NCIT_P399 "771520" @default.
- NCIT_C121849 normalizedInformationContent "100" @default.
- NCIT_C121849 referenceCount "1" @default.
- NCIT_C121849 hasExactSynonym "BET Inhibitor BMS-986158" @default.
- NCIT_C121849 hasExactSynonym "BMS-986158" @default.
- NCIT_C121849 inSubset NCIT_C116977 @default.
- NCIT_C121849 inSubset NCIT_C116978 @default.
- NCIT_C121849 inSubset NCIT_C128784 @default.
- NCIT_C121849 inSubset NCIT_C157711 @default.
- NCIT_C121849 inSubset NCIT_C157712 @default.
- NCIT_C121849 inSubset NCIT_C176424 @default.
- NCIT_C121849 inSubset NCIT_C177537 @default.
- NCIT_C121849 inSubset NCIT_C63923 @default.
- NCIT_C121849 type Class @default.
- NCIT_C121849 isDefinedBy ncit.owl @default.
- NCIT_C121849 label "BET Inhibitor BMS-986158" @default.
- NCIT_C121849 subClassOf NCIT_C121849 @default.
- NCIT_C121849 subClassOf NCIT_C128462 @default.
- NCIT_C121849 subClassOf NCIT_C129824 @default.
- NCIT_C121849 subClassOf NCIT_C1908 @default.
- NCIT_C121849 subClassOf NCIT_C1909 @default.
- NCIT_C121849 subClassOf NCIT_C2189 @default.
- NCIT_C121849 subClassOf NCIT_C274 @default.