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- NCIT_C121928 IAO_0000115 "A radioimmunoconjugate containing a bivalent monospecific tandem immunoglobulin fragment (B-Fab) derived from the humanized monoclonal antibody DS6 targeting the tumor-associated mucin-1 (MUC1)-sialoglycotope CA6 conjugated with the bifunctional, macrocyclic chelating agent 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) and labeled with the radioisotope copper Cu 64 with potential use as an imaging agent for CA6-expressing tumors using positron emission tomography (PET). The B-Fab moiety of Copper Cu 64-DOTA B-Fab binds, with high affinity, to the cell surface antigen CA6. Upon binding, the radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification of CA6-expressing tumor cells. This tracer could be used to select patients who could benefit from and to monitor efficacy of CA6-targeted anti-cancer therapies. Compared to DS6, the antibody fragment allows for increased tumor penetration, faster blood clearance, and more rapid renal elimination. The CA6 epitope is found on a variety of solid tumors." @default.
- NCIT_C121928 NCIT_NHC0 "C121928" @default.
- NCIT_C121928 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C121928 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121928 NCIT_P107 "Copper Cu 64-DOTA B-Fab" @default.
- NCIT_C121928 NCIT_P108 "Copper Cu 64-DOTA B-Fab" @default.
- NCIT_C121928 NCIT_P207 "C4055180" @default.
- NCIT_C121928 NCIT_P322 "CTRP" @default.
- NCIT_C121928 NCIT_P329 "780300" @default.
- NCIT_C121928 NCIT_P330 "780300" @default.
- NCIT_C121928 NCIT_P399 "780300" @default.
- NCIT_C121928 normalizedInformationContent "100" @default.
- NCIT_C121928 referenceCount "1" @default.
- NCIT_C121928 hasExactSynonym "64 Cu-DOTA B-Fab" @default.
- NCIT_C121928 hasExactSynonym "64 Cu-DOTA DS6 B-Fab" @default.
- NCIT_C121928 hasExactSynonym "Copper Cu 64-DOTA B-Fab" @default.
- NCIT_C121928 hasExactSynonym "Cu 64-labeled B-Fab DS6 Antibody-like Binding Protein" @default.
- NCIT_C121928 inSubset NCIT_C116977 @default.
- NCIT_C121928 inSubset NCIT_C116978 @default.
- NCIT_C121928 inSubset NCIT_C176424 @default.
- NCIT_C121928 type Class @default.
- NCIT_C121928 isDefinedBy ncit.owl @default.
- NCIT_C121928 label "Copper Cu 64-DOTA B-Fab" @default.
- NCIT_C121928 subClassOf NCIT_C121928 @default.
- NCIT_C121928 subClassOf NCIT_C1446 @default.
- NCIT_C121928 subClassOf NCIT_C1511 @default.
- NCIT_C121928 subClassOf NCIT_C1512 @default.
- NCIT_C121928 subClassOf NCIT_C1908 @default.
- NCIT_C121928 subClassOf NCIT_C1909 @default.
- NCIT_C121928 subClassOf NCIT_C2124 @default.
- NCIT_C121928 subClassOf NCIT_C307 @default.
- NCIT_C121928 subClassOf NCIT_C308 @default.