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- NCIT_C121943 IAO_0000115 "An orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Upon oral administration, selonsertib targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. This prevents the phosphorylation of downstream kinases, such as c-Jun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinase (p38 MAPK). By preventing the activation of ASK1-dependent signal transduction pathways, GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation. ASK1, also called mitogen-activated protein kinase kinase kinase 5 (MAP3K5), is activated in response to oxidative and endoplasmic reticulum (ER) stress, calcium influx and infection. It plays a key role in the development of certain cardiovascular and neurodegenerative diseases, diabetes, as well as certain types of cancer." @default.
- NCIT_C121943 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121943 NCIT_A7 NCIT_C106623 @default.
- NCIT_C121943 NCIT_NHC0 "C121943" @default.
- NCIT_C121943 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121943 NCIT_P107 "Selonsertib" @default.
- NCIT_C121943 NCIT_P108 "Selonsertib" @default.
- NCIT_C121943 NCIT_P207 "C4053640" @default.
- NCIT_C121943 NCIT_P210 "1448428-04-3" @default.
- NCIT_C121943 NCIT_P319 "NS3988A2TC" @default.
- NCIT_C121943 NCIT_P322 "CTRP" @default.
- NCIT_C121943 NCIT_P322 "FDA" @default.
- NCIT_C121943 NCIT_P322 "GDC" @default.
- NCIT_C121943 NCIT_P329 "773700" @default.
- NCIT_C121943 NCIT_P330 "773700" @default.
- NCIT_C121943 NCIT_P375 "Selonsertib" @default.
- NCIT_C121943 NCIT_P399 "773700" @default.
- NCIT_C121943 normalizedInformationContent "100" @default.
- NCIT_C121943 referenceCount "1" @default.
- NCIT_C121943 hasExactSynonym "GS-4997" @default.
- NCIT_C121943 hasExactSynonym "SELONSERTIB" @default.
- NCIT_C121943 hasExactSynonym "Selonsertib" @default.
- NCIT_C121943 inSubset NCIT_C116977 @default.
- NCIT_C121943 inSubset NCIT_C116978 @default.
- NCIT_C121943 inSubset NCIT_C128784 @default.
- NCIT_C121943 inSubset NCIT_C157711 @default.
- NCIT_C121943 inSubset NCIT_C157712 @default.
- NCIT_C121943 inSubset NCIT_C176424 @default.
- NCIT_C121943 inSubset NCIT_C177537 @default.
- NCIT_C121943 inSubset NCIT_C63923 @default.
- NCIT_C121943 type Class @default.
- NCIT_C121943 isDefinedBy ncit.owl @default.
- NCIT_C121943 label "Selonsertib" @default.
- NCIT_C121943 subClassOf NCIT_C121943 @default.
- NCIT_C121943 subClassOf NCIT_C1404 @default.
- NCIT_C121943 subClassOf NCIT_C1908 @default.
- NCIT_C121943 subClassOf NCIT_C1909 @default.
- NCIT_C121943 subClassOf NCIT_C471 @default.
- NCIT_C121943 subClassOf NCIT_C61074 @default.