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- NCIT_C121949 IAO_0000115 "An immunoconjugate consisting of a human immunoglobulin (Ig) G1 monoclonal antibody directed against the alpha subunit of the interleukin-2 receptor (IL-2R alpha or CD25) and conjugated, via a cleavable linker, to a synthetic, cross-linking agent pyrrolobenzodiazepine (PBD) dimer that targets DNA minor grooves, with potential antineoplastic activity. The monoclonal antibody portion of the anti-CD25 antibody-drug conjugate (ADC) ADCT-301 specifically binds to the cell surface antigen CD25. This causes the internalization of ADCT-301 and the subsequent release of the cytotoxic PBD moiety. The imine groups of the PBD moiety bind to the N2 positions of guanines on opposite strands of DNA. This induces interstrand cross-links in the minor groove of DNA and inhibits DNA replication, which inhibits the proliferation of CD25-overexpressing tumor cells. CD25, a transmembrane receptor and tumor-associated antigen (TAA), is expressed on certain cancer cells." @default.
- NCIT_C121949 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121949 NCIT_A7 NCIT_C17073 @default.
- NCIT_C121949 NCIT_NHC0 "C121949" @default.
- NCIT_C121949 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C121949 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C121949 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121949 NCIT_P107 "Camidanlumab Tesirine" @default.
- NCIT_C121949 NCIT_P108 "Camidanlumab Tesirine" @default.
- NCIT_C121949 NCIT_P207 "C4053683" @default.
- NCIT_C121949 NCIT_P210 "1853239-04-9" @default.
- NCIT_C121949 NCIT_P319 "LYJ1AEJ9YH" @default.
- NCIT_C121949 NCIT_P322 "CTRP" @default.
- NCIT_C121949 NCIT_P322 "FDA" @default.
- NCIT_C121949 NCIT_P322 "GDC" @default.
- NCIT_C121949 NCIT_P329 "771992" @default.
- NCIT_C121949 NCIT_P330 "771992" @default.
- NCIT_C121949 NCIT_P375 "Anti-CD25-PBD Antibody-drug Conjugate ADCT-301" @default.
- NCIT_C121949 NCIT_P375 "Camidanlumab Tesirine" @default.
- NCIT_C121949 NCIT_P399 "771992" @default.
- NCIT_C121949 normalizedInformationContent "100" @default.
- NCIT_C121949 referenceCount "1" @default.
- NCIT_C121949 hasExactSynonym "ADC ADCT-301" @default.
- NCIT_C121949 hasExactSynonym "ADCT-301" @default.
- NCIT_C121949 hasExactSynonym "CAMIDANLUMAB TESIRINE" @default.
- NCIT_C121949 hasExactSynonym "Camidanlumab Tesirine" @default.
- NCIT_C121949 inSubset NCIT_C116977 @default.
- NCIT_C121949 inSubset NCIT_C116978 @default.
- NCIT_C121949 inSubset NCIT_C128784 @default.
- NCIT_C121949 inSubset NCIT_C157711 @default.
- NCIT_C121949 inSubset NCIT_C157712 @default.
- NCIT_C121949 inSubset NCIT_C176424 @default.
- NCIT_C121949 inSubset NCIT_C177537 @default.
- NCIT_C121949 inSubset NCIT_C63923 @default.
- NCIT_C121949 type Class @default.
- NCIT_C121949 isDefinedBy ncit.owl @default.
- NCIT_C121949 label "Camidanlumab Tesirine" @default.
- NCIT_C121949 subClassOf NCIT_C121949 @default.
- NCIT_C121949 subClassOf NCIT_C129821 @default.
- NCIT_C121949 subClassOf NCIT_C129823 @default.
- NCIT_C121949 subClassOf NCIT_C1512 @default.
- NCIT_C121949 subClassOf NCIT_C1908 @default.
- NCIT_C121949 subClassOf NCIT_C1909 @default.
- NCIT_C121949 subClassOf NCIT_C274 @default.
- NCIT_C121949 subClassOf NCIT_C307 @default.
- NCIT_C121949 subClassOf NCIT_C308 @default.