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- NCIT_C121950 IAO_0000115 "A prenylated flavonoid derived from the female flowers of the hops plant (Humulus lupulus L), with potential chemopreventive and antineoplastic activities. Upon administration, xanthohumol scavenges reactive oxygen species (ROS), thereby preventing DNA damage due to oxidative stress. In addition, xanthohumol is able to increase the expression of phase II cytoprotective enzymes, thereby inactivating carcinogens. This agent exerts anti-inflammatory activity, through the inhibition of inflammation-inducing enzymes, inhibits DNA synthesis, and induces apoptosis of susceptible cancer cells. Xanthohumol also decreases the expression of C-X-C chemokine receptor 4 (CXCR4), thereby preventing cancer cell invasion." @default.
- NCIT_C121950 NCIT_A32 NCIT_C1909 @default.
- NCIT_C121950 NCIT_NHC0 "C121950" @default.
- NCIT_C121950 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C121950 NCIT_P108 "Xanthohumol" @default.
- NCIT_C121950 NCIT_P207 "C0536128" @default.
- NCIT_C121950 NCIT_P210 "6754-58-1" @default.
- NCIT_C121950 NCIT_P319 "T4467YT1NT" @default.
- NCIT_C121950 NCIT_P322 "FDA" @default.
- NCIT_C121950 NCIT_P322 "GDC" @default.
- NCIT_C121950 NCIT_P329 "772021" @default.
- NCIT_C121950 NCIT_P330 "772021" @default.
- NCIT_C121950 NCIT_P375 "Xanthohumol" @default.
- NCIT_C121950 NCIT_P399 "772021" @default.
- NCIT_C121950 normalizedInformationContent "100" @default.
- NCIT_C121950 referenceCount "1" @default.
- NCIT_C121950 hasExactSynonym "3'-[3,3-Dimethyl allyl]-2',4',4-trihydroxy-6'-methoxychalcone" @default.
- NCIT_C121950 hasExactSynonym "XANTHOHUMOL" @default.
- NCIT_C121950 hasExactSynonym "Xanthohumol" @default.
- NCIT_C121950 inSubset NCIT_C128784 @default.
- NCIT_C121950 inSubset NCIT_C157711 @default.
- NCIT_C121950 inSubset NCIT_C157712 @default.
- NCIT_C121950 inSubset NCIT_C176424 @default.
- NCIT_C121950 inSubset NCIT_C177537 @default.
- NCIT_C121950 inSubset NCIT_C63923 @default.
- NCIT_C121950 type Class @default.
- NCIT_C121950 isDefinedBy ncit.owl @default.
- NCIT_C121950 label "Xanthohumol" @default.
- NCIT_C121950 subClassOf NCIT_C107589 @default.
- NCIT_C121950 subClassOf NCIT_C121950 @default.
- NCIT_C121950 subClassOf NCIT_C1892 @default.
- NCIT_C121950 subClassOf NCIT_C1908 @default.
- NCIT_C121950 subClassOf NCIT_C1909 @default.
- NCIT_C121950 subClassOf NCIT_C308 @default.
- NCIT_C121950 subClassOf NCIT_C63817 @default.