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- NCIT_C122036 IAO_0000115 "A radioconjugate consisting of consisting of the high affinity somatostatin analogue iodo-tyrosine-3-octreotate (HA-TATE), labeled with the positron emission tomography (PET) tracer gallium Ga 68 via the macrocyclic chelating agent 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA), which may be used as a human somatostatin receptor (SSTR) imaging agent in conjunction with PET to image neuroendocrine tumors (NETs). Gallium Ga 68-HA-DOTATATE binds to SSTRs, with high affinity for SSTR2, present on the cell membranes of many types of NETs. This allows for visualization of SSTR-positive cells upon imaging. SSTRs have been shown to be present in large numbers on NETs and their metastases, while most other normal tissues express low levels of SSTRs. HA-TATE is an octreotide derivative in which phenylalanine at position 3 is substituted with iodo-tyrosine and threoninol at position 8 is replaced by threonine. The iodo addition in Gallium Ga 68-HA-DOTA-TATE may allow for higher affinity for the SSTRs when compared to gallium Ga 68-DOTA-TATE." @default.
- NCIT_C122036 NCIT_A7 NCIT_C17333 @default.
- NCIT_C122036 NCIT_A7 NCIT_C17922 @default.
- NCIT_C122036 NCIT_NHC0 "C122036" @default.
- NCIT_C122036 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122036 NCIT_P107 "Gallium Ga 68-HA-DOTA-TATE" @default.
- NCIT_C122036 NCIT_P108 "Gallium Ga 68-HA-DOTA-TATE" @default.
- NCIT_C122036 NCIT_P207 "C4042682" @default.
- NCIT_C122036 NCIT_P322 "CTRP" @default.
- NCIT_C122036 normalizedInformationContent "100" @default.
- NCIT_C122036 referenceCount "1" @default.
- NCIT_C122036 hasExactSynonym "68Ga-DOTA-3-iodo-Tyr3-octreotate" @default.
- NCIT_C122036 hasExactSynonym "68Ga-DOTA-iodoTyr3-octreotate" @default.
- NCIT_C122036 hasExactSynonym "68Ga-HA-DOTATATE" @default.
- NCIT_C122036 hasExactSynonym "Gallium Ga 68-HA-DOTA-TATE" @default.
- NCIT_C122036 hasExactSynonym "[68Ga]DOTA-3-iodo-Tyr3-octreotate" @default.
- NCIT_C122036 hasExactSynonym "[68Ga]high-affinity DOTATATE" @default.
- NCIT_C122036 inSubset NCIT_C116977 @default.
- NCIT_C122036 inSubset NCIT_C116978 @default.
- NCIT_C122036 type Class @default.
- NCIT_C122036 isDefinedBy ncit.owl @default.
- NCIT_C122036 label "Gallium Ga 68-HA-DOTA-TATE" @default.
- NCIT_C122036 subClassOf NCIT_C122036 @default.
- NCIT_C122036 subClassOf NCIT_C1446 @default.
- NCIT_C122036 subClassOf NCIT_C1908 @default.
- NCIT_C122036 subClassOf NCIT_C1909 @default.
- NCIT_C122036 subClassOf NCIT_C2124 @default.