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- NCIT_C122396 IAO_0000115 "A RNA-lipoplex (RNA-LIP)-based cancer vaccine containing four naked ribonucleic acid (RNA)-drug products (DPs) RBL001.1, RBL002.2, RBL003.1, and RBL004.1 encoding the four melanoma-associated antigens (MAAs), the cancer-testis antigen NY-ESO-1, the human melanoma-associated antigen A3 (MAGE-A3), tyrosinase, and putative tyrosine-protein phosphatase (TPTE), encapsulated in liposomes, with potential antineoplastic activity. Upon intravenous administration of the tetravalent RNA-lipoplex cancer vaccine BNT111, the liposomes protect the RNA from degradation in the bloodstream, travel to the spleen and are taken up by antigen-presenting cells (APCs). The RNA is translocated to the cytoplasm and translated into the four tumor-associated proteins. The expressed proteins are processed and the human leukocyte antigen (HLA)-peptide complexes are presented to the immune system. This results in the production of various pro-inflammatory cytokines and induces antigen-specific CD8+ and CD4+ T-cell responses against the four selected MAAs NY-ESO-1, MAGE-A3, tyrosinase, and TPTE." @default.
- NCIT_C122396 NCIT_A7 NCIT_C17226 @default.
- NCIT_C122396 NCIT_A7 NCIT_C17513 @default.
- NCIT_C122396 NCIT_A7 NCIT_C178153 @default.
- NCIT_C122396 NCIT_A7 NCIT_C39286 @default.
- NCIT_C122396 NCIT_NHC0 "C122396" @default.
- NCIT_C122396 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C122396 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122396 NCIT_P107 "Tetravalent RNA-lipoplex Cancer Vaccine BNT111" @default.
- NCIT_C122396 NCIT_P108 "Tetravalent RNA-lipoplex Cancer Vaccine BNT111" @default.
- NCIT_C122396 NCIT_P207 "C4053753" @default.
- NCIT_C122396 NCIT_P322 "CTRP" @default.
- NCIT_C122396 NCIT_P329 "772398" @default.
- NCIT_C122396 NCIT_P330 "772398" @default.
- NCIT_C122396 NCIT_P399 "772398" @default.
- NCIT_C122396 normalizedInformationContent "100" @default.
- NCIT_C122396 referenceCount "1" @default.
- NCIT_C122396 hasExactSynonym "BNT 111" @default.
- NCIT_C122396 hasExactSynonym "BNT-111" @default.
- NCIT_C122396 hasExactSynonym "BNT111" @default.
- NCIT_C122396 hasExactSynonym "Cancer Vaccine BNT111" @default.
- NCIT_C122396 hasExactSynonym "Lipo-MERIT Vaccine" @default.
- NCIT_C122396 hasExactSynonym "RNA(LIP) BNT111" @default.
- NCIT_C122396 hasExactSynonym "RNA-LPX BNT111" @default.
- NCIT_C122396 hasExactSynonym "RNA-lipoplex Vaccine BNT111" @default.
- NCIT_C122396 hasExactSynonym "Tetravalent RNA-lipoplex Cancer Vaccine BNT111" @default.
- NCIT_C122396 inSubset NCIT_C116977 @default.
- NCIT_C122396 inSubset NCIT_C116978 @default.
- NCIT_C122396 inSubset NCIT_C128784 @default.
- NCIT_C122396 inSubset NCIT_C176424 @default.
- NCIT_C122396 type Class @default.
- NCIT_C122396 isDefinedBy ncit.owl @default.
- NCIT_C122396 label "Tetravalent RNA-lipoplex Cancer Vaccine BNT111" @default.
- NCIT_C122396 subClassOf NCIT_C122396 @default.
- NCIT_C122396 subClassOf NCIT_C129820 @default.
- NCIT_C122396 subClassOf NCIT_C1663 @default.
- NCIT_C122396 subClassOf NCIT_C1908 @default.
- NCIT_C122396 subClassOf NCIT_C1909 @default.
- NCIT_C122396 subClassOf NCIT_C274 @default.
- NCIT_C122396 subClassOf NCIT_C307 @default.
- NCIT_C122396 subClassOf NCIT_C308 @default.
- NCIT_C122396 subClassOf NCIT_C923 @default.