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- NCIT_C122397 IAO_0000115 "A humanized, high-chimeric antibody targeting the human cell surface antigen CD47, with potential phagocytosis-inducing and antineoplastic activities. Upon administration, chimeric humanized anti-CD47 antibody selectively binds to CD47 expressed on tumor cells and blocks the interaction of CD47 with signal regulatory protein alpha (SIRPa), a protein expressed on phagocytic cells. This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated inhibition of phagocytosis. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein-1 (LRP-1), expressed on macrophages. This results in macrophage activation and the specific phagocytosis of tumor cells. In addition, blocking CD47 signaling activates both an anti-tumor T-lymphocyte immune response and T cell-mediated killing of CD47-expressing tumor cells. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSC) and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPa, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, which allows cancer cells to proliferate." @default.
- NCIT_C122397 NCIT_NHC0 "C122397" @default.
- NCIT_C122397 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122397 NCIT_P108 "Chimeric Humanized Anti-CD47 Antibody" @default.
- NCIT_C122397 NCIT_P207 "C4053733" @default.
- NCIT_C122397 NCIT_P329 "772446" @default.
- NCIT_C122397 NCIT_P330 "772446" @default.
- NCIT_C122397 NCIT_P399 "772446" @default.
- NCIT_C122397 NCIT_R124 NCIT_C17710 @default.
- NCIT_C122397 NCIT_R124 NCIT_C17828 @default.
- NCIT_C122397 NCIT_R124 NCIT_C18219 @default.
- NCIT_C122397 NCIT_R124 NCIT_C19986 @default.
- NCIT_C122397 NCIT_R124 NCIT_C40474 @default.
- NCIT_C122397 normalizedInformationContent "100" @default.
- NCIT_C122397 referenceCount "1" @default.
- NCIT_C122397 hasExactSynonym "Chimeric Humanized Anti-CD47 Antibody" @default.
- NCIT_C122397 hasExactSynonym "Humanized High-chimeric Antibody CD47" @default.
- NCIT_C122397 inSubset NCIT_C128784 @default.
- NCIT_C122397 inSubset NCIT_C176424 @default.
- NCIT_C122397 type Class @default.
- NCIT_C122397 isDefinedBy ncit.owl @default.
- NCIT_C122397 label "Chimeric Humanized Anti-CD47 Antibody" @default.
- NCIT_C122397 subClassOf NCIT_C122397 @default.
- NCIT_C122397 subClassOf NCIT_C129821 @default.
- NCIT_C122397 subClassOf NCIT_C129822 @default.
- NCIT_C122397 subClassOf NCIT_C159583 @default.
- NCIT_C122397 subClassOf NCIT_C163758 @default.
- NCIT_C122397 subClassOf NCIT_C1908 @default.
- NCIT_C122397 subClassOf NCIT_C1909 @default.
- NCIT_C122397 subClassOf NCIT_C192655 @default.
- NCIT_C122397 subClassOf NCIT_C20401 @default.
- NCIT_C122397 subClassOf NCIT_C274 @default.
- NCIT_C122397 subClassOf NCIT_C307 @default.
- NCIT_C122397 subClassOf NCIT_C308 @default.