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- NCIT_C122400 IAO_0000115 "A topical ointment formulation containing a synthetic form of hypericin, an anthraquinone derivative that is naturally found in the yellow flower of Hypericum perforatum (St. John's wort), with potential antineoplastic and photosensitizing activities. Upon topical administration of the ointment to the tumor site, hypericin becomes activated through the application of visible fluorescent light. During photoactivation, hypericin generates singlet oxygen, which induces DNA damage, necrosis and apoptosis, thereby inhibiting tumor cell growth. The use of visible light for activation avoids the risk of developing secondary malignancies, which are frequently associated with other photodynamic therapies that are dependent on ultraviolet A exposure." @default.
- NCIT_C122400 NCIT_A32 NCIT_C1909 @default.
- NCIT_C122400 NCIT_NHC0 "C122400" @default.
- NCIT_C122400 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122400 NCIT_P107 "Synthetic Hypericin" @default.
- NCIT_C122400 NCIT_P108 "Synthetic Hypericin" @default.
- NCIT_C122400 NCIT_P207 "C4053962" @default.
- NCIT_C122400 NCIT_P322 "CTRP" @default.
- NCIT_C122400 NCIT_P322 "GDC" @default.
- NCIT_C122400 NCIT_P329 "772561" @default.
- NCIT_C122400 NCIT_P330 "772561" @default.
- NCIT_C122400 NCIT_P375 "Synthetic Hypericin" @default.
- NCIT_C122400 NCIT_P399 "772561" @default.
- NCIT_C122400 normalizedInformationContent "100" @default.
- NCIT_C122400 referenceCount "1" @default.
- NCIT_C122400 hasExactSynonym "Synthetic Hypericin" @default.
- NCIT_C122400 hasExactSynonym "Topical SGX301" @default.
- NCIT_C122400 inSubset NCIT_C116977 @default.
- NCIT_C122400 inSubset NCIT_C116978 @default.
- NCIT_C122400 inSubset NCIT_C128784 @default.
- NCIT_C122400 inSubset NCIT_C157711 @default.
- NCIT_C122400 inSubset NCIT_C157712 @default.
- NCIT_C122400 inSubset NCIT_C176424 @default.
- NCIT_C122400 inSubset NCIT_C177537 @default.
- NCIT_C122400 type Class @default.
- NCIT_C122400 isDefinedBy ncit.owl @default.
- NCIT_C122400 label "Synthetic Hypericin" @default.
- NCIT_C122400 subClassOf NCIT_C122400 @default.
- NCIT_C122400 subClassOf NCIT_C1420 @default.
- NCIT_C122400 subClassOf NCIT_C1908 @default.
- NCIT_C122400 subClassOf NCIT_C1909 @default.