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- NCIT_C122401 IAO_0000115 "A fusion protein complex composed of heterodimeric IL-15 (hetIL-15), which consists of a synthetic form of the endogenous cytokine interleukin-15 chain (IL-15) complexed to the soluble IL-15 binding protein IL-15 receptor alpha chain (IL-15Ra) (IL15:sIL-15Ra), with potential immunomodulatory, anti-infective and antineoplastic activities. Upon administration, hetIL-15 binds to the IL-2/IL-15 receptor beta-common gamma chain (IL-2Rbeta-gamma) receptor on natural killer (NK) and T-lymphocytes, which activates and increases the levels of NK cells and CD8+ and CD4+ T-cells. The T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. Altogether, this enhances tumor cell killing and decreases tumor cell proliferation. By coupling IL-15 to IL15Ra, this agent has an improved pharmacokinetic profile, shows an increased ability to bind IL-2Rbeta-gamma, and shows increased immunostimulatory activity as compared to IL-15 alone." @default.
- NCIT_C122401 NCIT_A32 NCIT_C1909 @default.
- NCIT_C122401 NCIT_NHC0 "C122401" @default.
- NCIT_C122401 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122401 NCIT_P108 "Heterodimeric Interleukin-15" @default.
- NCIT_C122401 NCIT_P207 "C4053488" @default.
- NCIT_C122401 NCIT_P322 "GDC" @default.
- NCIT_C122401 NCIT_P329 "772563" @default.
- NCIT_C122401 NCIT_P330 "772563" @default.
- NCIT_C122401 NCIT_P375 "Heterodimeric Interleukin-15" @default.
- NCIT_C122401 NCIT_P399 "772563" @default.
- NCIT_C122401 normalizedInformationContent "100" @default.
- NCIT_C122401 referenceCount "1" @default.
- NCIT_C122401 hasExactSynonym "Heterodimeric Interleukin-15" @default.
- NCIT_C122401 hasExactSynonym "IL-15/sIL-15Ra" @default.
- NCIT_C122401 hasExactSynonym "hetIL-15" @default.
- NCIT_C122401 inSubset NCIT_C128784 @default.
- NCIT_C122401 inSubset NCIT_C157711 @default.
- NCIT_C122401 inSubset NCIT_C157712 @default.
- NCIT_C122401 inSubset NCIT_C176424 @default.
- NCIT_C122401 inSubset NCIT_C177537 @default.
- NCIT_C122401 type Class @default.
- NCIT_C122401 isDefinedBy ncit.owl @default.
- NCIT_C122401 label "Heterodimeric Interleukin-15" @default.
- NCIT_C122401 subClassOf NCIT_C122401 @default.
- NCIT_C122401 subClassOf NCIT_C129820 @default.
- NCIT_C122401 subClassOf NCIT_C129821 @default.
- NCIT_C122401 subClassOf NCIT_C1908 @default.
- NCIT_C122401 subClassOf NCIT_C1909 @default.
- NCIT_C122401 subClassOf NCIT_C274 @default.
- NCIT_C122401 subClassOf NCIT_C307 @default.
- NCIT_C122401 subClassOf NCIT_C308 @default.