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- NCIT_C122405 IAO_0000115 "A radioimmunoconjugate consisting of a chimeric monoclonal antibody targeting human cadherin-3 (CDH3) and labeled, via the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), with the beta-emitting radioisotope yttrium Y 90, with potential antineoplastic activities. Upon administration, the antibody moiety of yttrium Y 90 anti-CDH3 monoclonal antibody FF-21101 binds to CDH3 expressed on tumor cells, thereby specifically delivering cytotoxic beta radiation to CDH3-expressing tumor cells. CDH3, also known as P-cadherin, is a tumor-associated antigen (TAA) and member of the cadherin family; it is overexpressed in a variety of tumors and plays a role in cell adhesion, motility, invasion, and proliferation." @default.
- NCIT_C122405 NCIT_A32 NCIT_C1909 @default.
- NCIT_C122405 NCIT_A7 NCIT_C21020 @default.
- NCIT_C122405 NCIT_NHC0 "C122405" @default.
- NCIT_C122405 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C122405 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122405 NCIT_P107 "Yttrium Y 90 Anti-CDH3 Monoclonal Antibody FF-21101" @default.
- NCIT_C122405 NCIT_P108 "Yttrium Y 90 Anti-CDH3 Monoclonal Antibody FF-21101" @default.
- NCIT_C122405 NCIT_P207 "C4053526" @default.
- NCIT_C122405 NCIT_P322 "CTRP" @default.
- NCIT_C122405 NCIT_P322 "GDC" @default.
- NCIT_C122405 NCIT_P329 "772801" @default.
- NCIT_C122405 NCIT_P330 "772801" @default.
- NCIT_C122405 NCIT_P375 "Yttrium Y 90 Anti-CDH3 Monoclonal Antibody FF-21101" @default.
- NCIT_C122405 NCIT_P399 "772801" @default.
- NCIT_C122405 normalizedInformationContent "100" @default.
- NCIT_C122405 referenceCount "1" @default.
- NCIT_C122405 hasExactSynonym "FF-21101(90Y)" @default.
- NCIT_C122405 hasExactSynonym "Yttrium Y 90 Anti-CDH3 Monoclonal Antibody FF-21101" @default.
- NCIT_C122405 inSubset NCIT_C116977 @default.
- NCIT_C122405 inSubset NCIT_C116978 @default.
- NCIT_C122405 inSubset NCIT_C128784 @default.
- NCIT_C122405 inSubset NCIT_C157711 @default.
- NCIT_C122405 inSubset NCIT_C157712 @default.
- NCIT_C122405 inSubset NCIT_C176424 @default.
- NCIT_C122405 inSubset NCIT_C177537 @default.
- NCIT_C122405 type Class @default.
- NCIT_C122405 isDefinedBy ncit.owl @default.
- NCIT_C122405 label "Yttrium Y 90 Anti-CDH3 Monoclonal Antibody FF-21101" @default.
- NCIT_C122405 subClassOf NCIT_C122405 @default.
- NCIT_C122405 subClassOf NCIT_C129819 @default.
- NCIT_C122405 subClassOf NCIT_C1446 @default.
- NCIT_C122405 subClassOf NCIT_C1511 @default.
- NCIT_C122405 subClassOf NCIT_C1512 @default.
- NCIT_C122405 subClassOf NCIT_C1908 @default.
- NCIT_C122405 subClassOf NCIT_C1909 @default.
- NCIT_C122405 subClassOf NCIT_C2124 @default.
- NCIT_C122405 subClassOf NCIT_C274 @default.
- NCIT_C122405 subClassOf NCIT_C307 @default.
- NCIT_C122405 subClassOf NCIT_C308 @default.