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- NCIT_C122677 IAO_0000115 "A radioconjugate composed of gilteritinib, an inhibitor of the receptor tyrosine kinases (RTKs) FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2), AXL (UFO or JTK11) and anaplastic lymphoma kinase (ALK or CD246), labeled with the radioisotope carbon C 14, with potential use for evaluating the pharmacokinetic profile of gilteritinib. Gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL and ALK. This may result in an inhibition of FLT3, AXL, and ALK-mediated signal transduction pathways and the reduction of tumor cell proliferation in cancers that overexpress these RTKs. Labeling of gilteritinib with the radioactive tracer carbon C 14 allows for the evaluation of gilteritinib's pharmacokinetic profile, including its absorption, distribution, metabolism, and excretion (ADME)." @default.
- NCIT_C122677 NCIT_A7 NCIT_C17475 @default.
- NCIT_C122677 NCIT_A7 NCIT_C26202 @default.
- NCIT_C122677 NCIT_A7 NCIT_C27032 @default.
- NCIT_C122677 NCIT_NHC0 "C122677" @default.
- NCIT_C122677 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122677 NCIT_P107 "Carbon C 14 Gilteritinib" @default.
- NCIT_C122677 NCIT_P108 "Carbon C 14 Gilteritinib" @default.
- NCIT_C122677 NCIT_P207 "C4055274" @default.
- NCIT_C122677 NCIT_P322 "CTRP" @default.
- NCIT_C122677 NCIT_P329 "772842" @default.
- NCIT_C122677 NCIT_P330 "772842" @default.
- NCIT_C122677 NCIT_P399 "772842" @default.
- NCIT_C122677 normalizedInformationContent "100" @default.
- NCIT_C122677 referenceCount "1" @default.
- NCIT_C122677 hasExactSynonym "14C-labeled Gilteritinib" @default.
- NCIT_C122677 hasExactSynonym "Carbon C 14 Gilteritinib" @default.
- NCIT_C122677 hasExactSynonym "[14C] ASP2215" @default.
- NCIT_C122677 inSubset NCIT_C116977 @default.
- NCIT_C122677 inSubset NCIT_C116978 @default.
- NCIT_C122677 inSubset NCIT_C176424 @default.
- NCIT_C122677 type Class @default.
- NCIT_C122677 isDefinedBy ncit.owl @default.
- NCIT_C122677 label "Carbon C 14 Gilteritinib" @default.
- NCIT_C122677 subClassOf NCIT_C122677 @default.
- NCIT_C122677 subClassOf NCIT_C1446 @default.
- NCIT_C122677 subClassOf NCIT_C1908 @default.
- NCIT_C122677 subClassOf NCIT_C1909 @default.
- NCIT_C122677 subClassOf NCIT_C2124 @default.