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- NCIT_C122707 IAO_0000115 "An orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BAY 1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells. Mps1, a kinase expressed in proliferating normal tissues and aberrantly overexpressed in a wide range of human tumors, is activated during mitosis and is essential for proper SAC functioning and chromosome alignment." @default.
- NCIT_C122707 NCIT_A32 NCIT_C1909 @default.
- NCIT_C122707 NCIT_A7 NCIT_C30147 @default.
- NCIT_C122707 NCIT_NHC0 "C122707" @default.
- NCIT_C122707 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122707 NCIT_P107 "Mps1 Inhibitor BAY 1217389" @default.
- NCIT_C122707 NCIT_P108 "Mps1 Inhibitor BAY 1217389" @default.
- NCIT_C122707 NCIT_P207 "C4053670" @default.
- NCIT_C122707 NCIT_P322 "CTRP" @default.
- NCIT_C122707 NCIT_P322 "GDC" @default.
- NCIT_C122707 NCIT_P329 "769545" @default.
- NCIT_C122707 NCIT_P330 "769545" @default.
- NCIT_C122707 NCIT_P375 "Mps1 Inhibitor BAY 1217389" @default.
- NCIT_C122707 NCIT_P399 "769545" @default.
- NCIT_C122707 normalizedInformationContent "100" @default.
- NCIT_C122707 referenceCount "1" @default.
- NCIT_C122707 hasExactSynonym "BAY 1217389" @default.
- NCIT_C122707 hasExactSynonym "Mps1 Inhibitor BAY 1217389" @default.
- NCIT_C122707 hasExactSynonym "TTK Inhibitor BAY 1217389" @default.
- NCIT_C122707 inSubset NCIT_C116977 @default.
- NCIT_C122707 inSubset NCIT_C116978 @default.
- NCIT_C122707 inSubset NCIT_C128784 @default.
- NCIT_C122707 inSubset NCIT_C157711 @default.
- NCIT_C122707 inSubset NCIT_C157712 @default.
- NCIT_C122707 inSubset NCIT_C176424 @default.
- NCIT_C122707 inSubset NCIT_C177537 @default.
- NCIT_C122707 type Class @default.
- NCIT_C122707 isDefinedBy ncit.owl @default.
- NCIT_C122707 label "Mps1 Inhibitor BAY 1217389" @default.
- NCIT_C122707 subClassOf NCIT_C122707 @default.
- NCIT_C122707 subClassOf NCIT_C129824 @default.
- NCIT_C122707 subClassOf NCIT_C129825 @default.
- NCIT_C122707 subClassOf NCIT_C1404 @default.
- NCIT_C122707 subClassOf NCIT_C1908 @default.
- NCIT_C122707 subClassOf NCIT_C1909 @default.
- NCIT_C122707 subClassOf NCIT_C200085 @default.
- NCIT_C122707 subClassOf NCIT_C2189 @default.
- NCIT_C122707 subClassOf NCIT_C274 @default.
- NCIT_C122707 subClassOf NCIT_C471 @default.
- NCIT_C122707 subClassOf NCIT_C61074 @default.