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- NCIT_C122718 IAO_0000115 "A combination agent composed of two human monoclonal antibodies against the human cytomegalovirus (HCMV), LJP538 and LJP539, with potential immunomodulating activity. Upon administration of CSJ-148, both LJP538 and LJP539 bind to and inhibit the function of viral HCMV glycoproteins that are essential for HCMV infection; LJP538 targets and binds to glycoprotein B (gB) and LJP539 targets and inhibits the pentameric complex, consisting of glycoproteins gH, gL, UL128, UL130, and UL131. Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients." @default.
- NCIT_C122718 NCIT_NHC0 "C122718" @default.
- NCIT_C122718 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122718 NCIT_P107 "Anti-human Cytomegalovirus Monoclonal Antibody Combination CSJ-148" @default.
- NCIT_C122718 NCIT_P108 "Anti-human Cytomegalovirus Monoclonal Antibody Combination CSJ-148" @default.
- NCIT_C122718 NCIT_P207 "C4053652" @default.
- NCIT_C122718 NCIT_P322 "CTRP" @default.
- NCIT_C122718 NCIT_P329 "773824" @default.
- NCIT_C122718 NCIT_P330 "773824" @default.
- NCIT_C122718 NCIT_P399 "773824" @default.
- NCIT_C122718 normalizedInformationContent "100" @default.
- NCIT_C122718 referenceCount "1" @default.
- NCIT_C122718 hasExactSynonym "Anti-human Cytomegalovirus Monoclonal Antibody Combination CSJ-148" @default.
- NCIT_C122718 hasExactSynonym "Antiviral Agent CSJ148" @default.
- NCIT_C122718 hasExactSynonym "CSJ 148" @default.
- NCIT_C122718 hasExactSynonym "CSJ-148" @default.
- NCIT_C122718 hasExactSynonym "CSJ148" @default.
- NCIT_C122718 hasExactSynonym "HCMV Neutralizing Human mAb Combination CSJ-148" @default.
- NCIT_C122718 hasExactSynonym "LJP538 Plus LJP539" @default.
- NCIT_C122718 hasExactSynonym "LJP538 and LJP539" @default.
- NCIT_C122718 hasExactSynonym "LJP538/LJP539" @default.
- NCIT_C122718 inSubset NCIT_C116977 @default.
- NCIT_C122718 inSubset NCIT_C116978 @default.
- NCIT_C122718 inSubset NCIT_C176424 @default.
- NCIT_C122718 type Class @default.
- NCIT_C122718 isDefinedBy ncit.owl @default.
- NCIT_C122718 label "Anti-human Cytomegalovirus Monoclonal Antibody Combination CSJ-148" @default.
- NCIT_C122718 subClassOf NCIT_C122718 @default.
- NCIT_C122718 subClassOf NCIT_C1908 @default.
- NCIT_C122718 subClassOf NCIT_C1909 @default.
- NCIT_C122718 subClassOf NCIT_C254 @default.
- NCIT_C122718 subClassOf NCIT_C281 @default.