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- NCIT_C122816 IAO_0000115 "An antibody-drug conjugate (ADC) composed of an antibody targeting CS1 (SLAMF7/CD319) that is conjugated to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), via a cathepsin-cleavable linker, with potential antineoplastic activity. Upon administration, the antibody moiety of azintuxizumab vedotin binds to CS1-expressing tumor cells and is internalized, thereby delivering MMAE intracellularly. Upon cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M checkpoint arrest and apoptosis in CS1-expressing tumor cells. CS1 is a cell surface glycoprotein belonging to the CD2 subset of the immunoglobulin superfamily (IgSF) and is expressed with high levels and prevalence on multiple myeloma (MM) cells." @default.
- NCIT_C122816 NCIT_A32 NCIT_C1909 @default.
- NCIT_C122816 NCIT_A7 NCIT_C95308 @default.
- NCIT_C122816 NCIT_NHC0 "C122816" @default.
- NCIT_C122816 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122816 NCIT_P107 "Azintuxizumab Vedotin" @default.
- NCIT_C122816 NCIT_P108 "Azintuxizumab Vedotin" @default.
- NCIT_C122816 NCIT_P207 "C4053688" @default.
- NCIT_C122816 NCIT_P210 "1826819-58-2" @default.
- NCIT_C122816 NCIT_P319 "6XQ9TM3U2G" @default.
- NCIT_C122816 NCIT_P322 "CTRP" @default.
- NCIT_C122816 NCIT_P322 "FDA" @default.
- NCIT_C122816 NCIT_P322 "GDC" @default.
- NCIT_C122816 NCIT_P375 "Antibody-drug Conjugate ABBV-838" @default.
- NCIT_C122816 NCIT_P375 "Azintuxizumab Vedotin" @default.
- NCIT_C122816 normalizedInformationContent "100" @default.
- NCIT_C122816 referenceCount "1" @default.
- NCIT_C122816 hasExactSynonym "ABBV-838" @default.
- NCIT_C122816 hasExactSynonym "ADC ABBV-838" @default.
- NCIT_C122816 hasExactSynonym "AZINTUXIZUMAB VEDOTIN" @default.
- NCIT_C122816 hasExactSynonym "Azintuxizumab Vedotin" @default.
- NCIT_C122816 inSubset NCIT_C116977 @default.
- NCIT_C122816 inSubset NCIT_C116978 @default.
- NCIT_C122816 inSubset NCIT_C128784 @default.
- NCIT_C122816 inSubset NCIT_C157711 @default.
- NCIT_C122816 inSubset NCIT_C157712 @default.
- NCIT_C122816 inSubset NCIT_C177537 @default.
- NCIT_C122816 inSubset NCIT_C63923 @default.
- NCIT_C122816 type Class @default.
- NCIT_C122816 isDefinedBy ncit.owl @default.
- NCIT_C122816 label "Azintuxizumab Vedotin" @default.
- NCIT_C122816 subClassOf NCIT_C122816 @default.
- NCIT_C122816 subClassOf NCIT_C129821 @default.
- NCIT_C122816 subClassOf NCIT_C129823 @default.
- NCIT_C122816 subClassOf NCIT_C1512 @default.
- NCIT_C122816 subClassOf NCIT_C1908 @default.
- NCIT_C122816 subClassOf NCIT_C1909 @default.
- NCIT_C122816 subClassOf NCIT_C274 @default.
- NCIT_C122816 subClassOf NCIT_C307 @default.
- NCIT_C122816 subClassOf NCIT_C308 @default.