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- NCIT_C122835 IAO_0000115 "An orally bioavailable inhibitor of inosine 5'- monophosphate dehydrogenase (IMPDH), with potential antineoplastic activity. Upon administration, IMPDH inhibitor FF-10501-01 competitively inhibits the enzyme IMPDH, thereby preventing the conversion of inosine monophosphate to xanthosine monophosphate. This inhibits the synthesis of guanine nucleotides, deprives cancer cells of guanosine triphosphate (GTP), disrupts DNA and RNA synthesis, and decreases tumor cell proliferation. Tumor cells are highly susceptible to IMPDH inhibition because they are rapidly dividing cells that are dependent on rapid DNA synthesis, which requires a high concentration of nucleotides. IMPDH, an enzyme that catalyzes the rate-limiting step in the synthesis of guanosine triphosphate (GTP), is overexpressed in numerous tumor cell types." @default.
- NCIT_C122835 NCIT_A32 NCIT_C1909 @default.
- NCIT_C122835 NCIT_NHC0 "C122835" @default.
- NCIT_C122835 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122835 NCIT_P108 "Inosine 5'-monophosphate Dehydrogenase Inhibitor FF-10501-01" @default.
- NCIT_C122835 NCIT_P208 "CL474107" @default.
- NCIT_C122835 NCIT_P322 "GDC" @default.
- NCIT_C122835 NCIT_P329 "763219" @default.
- NCIT_C122835 NCIT_P330 "763219" @default.
- NCIT_C122835 NCIT_P375 "Inosine 5'-monophosphate Dehydrogenase Inhibitor FF-10501-01" @default.
- NCIT_C122835 NCIT_P399 "763219" @default.
- NCIT_C122835 normalizedInformationContent "100" @default.
- NCIT_C122835 referenceCount "1" @default.
- NCIT_C122835 hasExactSynonym "FF-10501" @default.
- NCIT_C122835 hasExactSynonym "FF-10501-01" @default.
- NCIT_C122835 hasExactSynonym "IMPDH Inhibitor FF-10501" @default.
- NCIT_C122835 hasExactSynonym "Inosine 5'-monophosphate Dehydrogenase Inhibitor FF-10501-01" @default.
- NCIT_C122835 inSubset NCIT_C128784 @default.
- NCIT_C122835 inSubset NCIT_C157711 @default.
- NCIT_C122835 inSubset NCIT_C157712 @default.
- NCIT_C122835 inSubset NCIT_C176424 @default.
- NCIT_C122835 inSubset NCIT_C177537 @default.
- NCIT_C122835 type Class @default.
- NCIT_C122835 isDefinedBy ncit.owl @default.
- NCIT_C122835 label "Inosine 5'-monophosphate Dehydrogenase Inhibitor FF-10501-01" @default.
- NCIT_C122835 subClassOf NCIT_C122835 @default.
- NCIT_C122835 subClassOf NCIT_C1908 @default.
- NCIT_C122835 subClassOf NCIT_C1909 @default.
- NCIT_C122835 subClassOf NCIT_C2087 @default.
- NCIT_C122835 subClassOf NCIT_C471 @default.