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- NCIT_C122921 IAO_0000115 "An immunoglobulin (Ig) G1 humanized monoclonal antibody targeting human R-spondin 3 (RSPO3), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, rosmantuzumab targets and binds to RSPO3 expressed on tumor cells. This prevents the activation of RSPO3, and inhibits both the binding of RSPO3 to leucine-rich repeat-containing G-coupled receptors (LGRs) and the activation of the RSPO-LGR pathway. This may result in an inhibition of both cancer stem cell (CSC) survival and the proliferation of cancer cells in which this pathway is overactivated. The RSPO-LGR pathway is a CSC pathway activated in a variety of cancer cell types." @default.
- NCIT_C122921 NCIT_A32 NCIT_C1909 @default.
- NCIT_C122921 NCIT_A7 NCIT_C29579 @default.
- NCIT_C122921 NCIT_NHC0 "C122921" @default.
- NCIT_C122921 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C122921 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C122921 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122921 NCIT_P107 "Rosmantuzumab" @default.
- NCIT_C122921 NCIT_P108 "Rosmantuzumab" @default.
- NCIT_C122921 NCIT_P207 "C4053609" @default.
- NCIT_C122921 NCIT_P210 "1684393-04-1" @default.
- NCIT_C122921 NCIT_P319 "VD026R6TCI" @default.
- NCIT_C122921 NCIT_P322 "CTRP" @default.
- NCIT_C122921 NCIT_P322 "FDA" @default.
- NCIT_C122921 NCIT_P322 "GDC" @default.
- NCIT_C122921 NCIT_P329 "774650" @default.
- NCIT_C122921 NCIT_P330 "774650" @default.
- NCIT_C122921 NCIT_P375 "Rosmantuzumab" @default.
- NCIT_C122921 NCIT_P399 "774650" @default.
- NCIT_C122921 NCIT_R124 NCIT_C17710 @default.
- NCIT_C122921 NCIT_R124 NCIT_C17828 @default.
- NCIT_C122921 NCIT_R124 NCIT_C18219 @default.
- NCIT_C122921 NCIT_R124 NCIT_C19986 @default.
- NCIT_C122921 NCIT_R124 NCIT_C40474 @default.
- NCIT_C122921 normalizedInformationContent "100" @default.
- NCIT_C122921 referenceCount "1" @default.
- NCIT_C122921 hasExactSynonym "OMP-131R10" @default.
- NCIT_C122921 hasExactSynonym "ROSMANTUZUMAB" @default.
- NCIT_C122921 hasExactSynonym "Rosmantuzumab" @default.
- NCIT_C122921 inSubset NCIT_C116977 @default.
- NCIT_C122921 inSubset NCIT_C116978 @default.
- NCIT_C122921 inSubset NCIT_C128784 @default.
- NCIT_C122921 inSubset NCIT_C157711 @default.
- NCIT_C122921 inSubset NCIT_C157712 @default.
- NCIT_C122921 inSubset NCIT_C176424 @default.
- NCIT_C122921 inSubset NCIT_C177537 @default.
- NCIT_C122921 inSubset NCIT_C63923 @default.
- NCIT_C122921 type Class @default.
- NCIT_C122921 isDefinedBy ncit.owl @default.
- NCIT_C122921 label "Rosmantuzumab" @default.
- NCIT_C122921 subClassOf NCIT_C122921 @default.
- NCIT_C122921 subClassOf NCIT_C129821 @default.
- NCIT_C122921 subClassOf NCIT_C129822 @default.
- NCIT_C122921 subClassOf NCIT_C1908 @default.
- NCIT_C122921 subClassOf NCIT_C1909 @default.
- NCIT_C122921 subClassOf NCIT_C20401 @default.
- NCIT_C122921 subClassOf NCIT_C274 @default.
- NCIT_C122921 subClassOf NCIT_C307 @default.
- NCIT_C122921 subClassOf NCIT_C308 @default.