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- NCIT_C122922 IAO_0000115 "An immunotherapeutic combination product composed of LV305, an engineered lentiviral vector that both targets dendritic cells (DCs) and contains nucleic acids encoding the human tumor-associated cancer-testis antigen NY-ESO-1 (CTAG1), and G305, a cancer vaccine comprised of an NY-ESO-1 recombinant protein and glucopyranosyl lipid adjuvant (GLA)-stable emulsion (GLA-SE), with potential synergistic immunostimulatory and antineoplastic activities. Upon intradermal administration of LV305, the DC-targeting lentiviral vector targets and binds to dermal DCs via the DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) receptor. Upon internalization of the vector, the NY-ESO-1 protein is expressed, which stimulates DC maturation, and activates the immune system to mount a cytotoxic T-lymphocyte (CTL) response against NY-ESO-1-expressing cells; this may result in tumor cell lysis. Upon the sequential intramuscular injection of G305, the adjuvant portion of G305 binds to toll-like receptor 4 (TLR-4) expressed on various immune cells, including DCs, monocytes, macrophages and B-cells. The activated DCs present the NY-ESO-1 antigen to CD4-positive Th1 T-lymphocytes. The induction of antigen-specific CD4-positive T-lymphocytes further induces a CTL response against NY-ESO-1-expressing tumor cells. In addition, G305 induces an NY-ESO-1-specific antibody response. NY-ESO-1, expressed in normal testes and on the surfaces of various tumor cells, plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C122922 NCIT_A32 NCIT_C1909 @default.
- NCIT_C122922 NCIT_A7 NCIT_C39286 @default.
- NCIT_C122922 NCIT_NHC0 "C122922" @default.
- NCIT_C122922 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122922 NCIT_P107 "Immunotherapeutic Combination Product CMB305" @default.
- NCIT_C122922 NCIT_P108 "Immunotherapeutic Combination Product CMB305" @default.
- NCIT_C122922 NCIT_P207 "C4053576" @default.
- NCIT_C122922 NCIT_P322 "CTRP" @default.
- NCIT_C122922 NCIT_P322 "GDC" @default.
- NCIT_C122922 NCIT_P329 "777295" @default.
- NCIT_C122922 NCIT_P330 "777295" @default.
- NCIT_C122922 NCIT_P375 "Immunotherapeutic Combination Product CMB305" @default.
- NCIT_C122922 NCIT_P399 "777295" @default.
- NCIT_C122922 normalizedInformationContent "100" @default.
- NCIT_C122922 referenceCount "1" @default.
- NCIT_C122922 hasExactSynonym "CMB 305" @default.
- NCIT_C122922 hasExactSynonym "CMB305" @default.
- NCIT_C122922 hasExactSynonym "ID-CMB305" @default.
- NCIT_C122922 hasExactSynonym "ID-LV305 Plus ID G305" @default.
- NCIT_C122922 hasExactSynonym "Immunotherapeutic Combination Product CMB305" @default.
- NCIT_C122922 hasExactSynonym "LV 305 Plus G 305" @default.
- NCIT_C122922 hasExactSynonym "LV305 Plus G305" @default.
- NCIT_C122922 inSubset NCIT_C116977 @default.
- NCIT_C122922 inSubset NCIT_C116978 @default.
- NCIT_C122922 inSubset NCIT_C128784 @default.
- NCIT_C122922 inSubset NCIT_C157711 @default.
- NCIT_C122922 inSubset NCIT_C157712 @default.
- NCIT_C122922 inSubset NCIT_C176424 @default.
- NCIT_C122922 inSubset NCIT_C177537 @default.
- NCIT_C122922 type Class @default.
- NCIT_C122922 isDefinedBy ncit.owl @default.
- NCIT_C122922 label "Immunotherapeutic Combination Product CMB305" @default.
- NCIT_C122922 subClassOf NCIT_C122922 @default.
- NCIT_C122922 subClassOf NCIT_C1908 @default.
- NCIT_C122922 subClassOf NCIT_C1909 @default.
- NCIT_C122922 subClassOf NCIT_C2139 @default.
- NCIT_C122922 subClassOf NCIT_C308 @default.