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- NCIT_C122924 IAO_0000115 "An antibody directed against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, anti-B7-H3 antibody DS-5573a binds to the cell surface antigen B7-H3, thereby blocking B7-H3-mediated signaling. This abrogates the inhibitory effect on T-cell activation and may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis." @default.
- NCIT_C122924 NCIT_A32 NCIT_C1909 @default.
- NCIT_C122924 NCIT_NHC0 "C122924" @default.
- NCIT_C122924 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C122924 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122924 NCIT_P108 "Anti-B7-H3 Antibody DS-5573a" @default.
- NCIT_C122924 NCIT_P208 "CL474104" @default.
- NCIT_C122924 NCIT_P322 "GDC" @default.
- NCIT_C122924 NCIT_P329 "763154" @default.
- NCIT_C122924 NCIT_P330 "763154" @default.
- NCIT_C122924 NCIT_P375 "Anti-B7-H3 Antibody DS-5573a" @default.
- NCIT_C122924 NCIT_P399 "763154" @default.
- NCIT_C122924 NCIT_R124 NCIT_C17710 @default.
- NCIT_C122924 NCIT_R124 NCIT_C17828 @default.
- NCIT_C122924 NCIT_R124 NCIT_C18219 @default.
- NCIT_C122924 NCIT_R124 NCIT_C19986 @default.
- NCIT_C122924 NCIT_R124 NCIT_C40474 @default.
- NCIT_C122924 normalizedInformationContent "100" @default.
- NCIT_C122924 referenceCount "1" @default.
- NCIT_C122924 hasExactSynonym "Anti-B7-H3 Antibody DS-5573a" @default.
- NCIT_C122924 hasExactSynonym "DS-5573a" @default.
- NCIT_C122924 inSubset NCIT_C128784 @default.
- NCIT_C122924 inSubset NCIT_C157711 @default.
- NCIT_C122924 inSubset NCIT_C157712 @default.
- NCIT_C122924 inSubset NCIT_C176424 @default.
- NCIT_C122924 inSubset NCIT_C177537 @default.
- NCIT_C122924 type Class @default.
- NCIT_C122924 isDefinedBy ncit.owl @default.
- NCIT_C122924 label "Anti-B7-H3 Antibody DS-5573a" @default.
- NCIT_C122924 subClassOf NCIT_C122924 @default.
- NCIT_C122924 subClassOf NCIT_C129821 @default.
- NCIT_C122924 subClassOf NCIT_C129822 @default.
- NCIT_C122924 subClassOf NCIT_C141144 @default.
- NCIT_C122924 subClassOf NCIT_C1908 @default.
- NCIT_C122924 subClassOf NCIT_C1909 @default.
- NCIT_C122924 subClassOf NCIT_C20401 @default.
- NCIT_C122924 subClassOf NCIT_C274 @default.
- NCIT_C122924 subClassOf NCIT_C307 @default.
- NCIT_C122924 subClassOf NCIT_C308 @default.