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- NCIT_C122986 IAO_0000115 "A combination agent composed of the two human monoclonal antibodies VAK694 (VAK296), targeting interleukin-4 (IL-4), and QAX576, targeting IL-13, that can potentially be used to block signaling mediated by IL-4 and IL-13. Upon intravenous administration of the anti-IL-4/IL-13 co,mbination agent QBX258, the two antibodies VAK694 and QAX576 target and block the activity of the two cytokines IL-4 and IL-13, respectively, which prevents IL-4/IL-13-mediated signaling. In patients with breast cancer related lymphedema (BCRL), this agent may prevent lymphedema-associated effects, such as fibrosis, hyperkeratosis, the deposition of fibroadipose tissue, fluid accumulation, limb swelling, reduction of skin elasticity, and pain. By reducing the excess volume, QBX258 may improve lymphatic and arm functions. The development of lymphedema after lymphatic injury is associated with tissue inflammation, the infiltration of CD4-positive cells and their differentiation to the type 2 helper T-cell (Th2) phenotype. Th2 cells produce IL-4 and IL-13 that play a key role in the development of lymphedema-associated symptoms as well as other Th2-mediated diseases." @default.
- NCIT_C122986 NCIT_A7 NCIT_C20508 @default.
- NCIT_C122986 NCIT_A7 NCIT_C20515 @default.
- NCIT_C122986 NCIT_NHC0 "C122986" @default.
- NCIT_C122986 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C122986 NCIT_P107 "Anti-IL-4/IL-13 Combination Agent QBX258" @default.
- NCIT_C122986 NCIT_P108 "Anti-IL-4/IL-13 Combination Agent QBX258" @default.
- NCIT_C122986 NCIT_P207 "C4053602" @default.
- NCIT_C122986 NCIT_P322 "CTRP" @default.
- NCIT_C122986 NCIT_P329 "774599" @default.
- NCIT_C122986 NCIT_P330 "774599" @default.
- NCIT_C122986 NCIT_P399 "774599" @default.
- NCIT_C122986 normalizedInformationContent "100" @default.
- NCIT_C122986 referenceCount "1" @default.
- NCIT_C122986 hasExactSynonym "Anti-IL-4/IL-13 Combination Agent QBX258" @default.
- NCIT_C122986 hasExactSynonym "QBX-258" @default.
- NCIT_C122986 hasExactSynonym "QBX258" @default.
- NCIT_C122986 hasExactSynonym "VAK296 Plus QAX576" @default.
- NCIT_C122986 hasExactSynonym "VAK296/QAX576" @default.
- NCIT_C122986 hasExactSynonym "VAK694 Plus QAX576" @default.
- NCIT_C122986 hasExactSynonym "VAK694/QAX576" @default.
- NCIT_C122986 inSubset NCIT_C116977 @default.
- NCIT_C122986 inSubset NCIT_C116978 @default.
- NCIT_C122986 inSubset NCIT_C176424 @default.
- NCIT_C122986 type Class @default.
- NCIT_C122986 isDefinedBy ncit.owl @default.
- NCIT_C122986 label "Anti-IL-4/IL-13 Combination Agent QBX258" @default.
- NCIT_C122986 subClassOf NCIT_C122986 @default.
- NCIT_C122986 subClassOf NCIT_C1908 @default.
- NCIT_C122986 subClassOf NCIT_C1909 @default.
- NCIT_C122986 subClassOf NCIT_C308 @default.