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- NCIT_C123332 IAO_0000115 "A proprietary recombinant bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) CD33 fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of eluvixtamab, this bispecific antibody binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the CD33 antigen found on CD33-expressing tumor cells. This activates and redirects CTLs to CD33-expressing tumor cells, which results in the CTL-mediated cell death of CD33-expressing tumor cells. CD33, a myeloid differentiation antigen, is expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on neoplastic cells in patients with acute myeloid leukemia." @default.
- NCIT_C123332 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123332 NCIT_A7 NCIT_C97246 @default.
- NCIT_C123332 NCIT_NHC0 "C123332" @default.
- NCIT_C123332 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C123332 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C123332 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123332 NCIT_P107 "Eluvixtamab" @default.
- NCIT_C123332 NCIT_P108 "Eluvixtamab" @default.
- NCIT_C123332 NCIT_P207 "C3851031" @default.
- NCIT_C123332 NCIT_P210 "1679391-73-1" @default.
- NCIT_C123332 NCIT_P319 "6Z4B5PJ4OP" @default.
- NCIT_C123332 NCIT_P322 "CTRP" @default.
- NCIT_C123332 NCIT_P322 "FDA" @default.
- NCIT_C123332 NCIT_P322 "GDC" @default.
- NCIT_C123332 NCIT_P329 "775135" @default.
- NCIT_C123332 NCIT_P330 "775135" @default.
- NCIT_C123332 NCIT_P375 "Anti-CD33/CD3 BiTE Antibody AMG 330" @default.
- NCIT_C123332 NCIT_P399 "775135" @default.
- NCIT_C123332 NCIT_R124 NCIT_C17710 @default.
- NCIT_C123332 NCIT_R124 NCIT_C17828 @default.
- NCIT_C123332 NCIT_R124 NCIT_C18219 @default.
- NCIT_C123332 NCIT_R124 NCIT_C19986 @default.
- NCIT_C123332 NCIT_R124 NCIT_C40474 @default.
- NCIT_C123332 normalizedInformationContent "100" @default.
- NCIT_C123332 referenceCount "1" @default.
- NCIT_C123332 hasExactSynonym "AMG 330" @default.
- NCIT_C123332 hasExactSynonym "AMG330" @default.
- NCIT_C123332 hasExactSynonym "Anti-CD33/CD3 BiTE Antibody AMG 330" @default.
- NCIT_C123332 hasExactSynonym "BiTE Antibody AMG 330" @default.
- NCIT_C123332 hasExactSynonym "Bispecific T-cell Engager Antibody AMG 330" @default.
- NCIT_C123332 hasExactSynonym "CD33/CD3-directed Bispecific T-cell Engager Antibody AMG 330" @default.
- NCIT_C123332 hasExactSynonym "ELUVIXTAMAB" @default.
- NCIT_C123332 hasExactSynonym "Eluvixtamab" @default.
- NCIT_C123332 inSubset NCIT_C116977 @default.
- NCIT_C123332 inSubset NCIT_C116978 @default.
- NCIT_C123332 inSubset NCIT_C128784 @default.
- NCIT_C123332 inSubset NCIT_C157711 @default.
- NCIT_C123332 inSubset NCIT_C157712 @default.
- NCIT_C123332 inSubset NCIT_C176424 @default.
- NCIT_C123332 inSubset NCIT_C177537 @default.
- NCIT_C123332 inSubset NCIT_C63923 @default.
- NCIT_C123332 type Class @default.
- NCIT_C123332 isDefinedBy ncit.owl @default.
- NCIT_C123332 label "Eluvixtamab" @default.
- NCIT_C123332 subClassOf NCIT_C112883 @default.
- NCIT_C123332 subClassOf NCIT_C123332 @default.
- NCIT_C123332 subClassOf NCIT_C129821 @default.
- NCIT_C123332 subClassOf NCIT_C129822 @default.
- NCIT_C123332 subClassOf NCIT_C1454 @default.
- NCIT_C123332 subClassOf NCIT_C1908 @default.
- NCIT_C123332 subClassOf NCIT_C1909 @default.
- NCIT_C123332 subClassOf NCIT_C200367 @default.
- NCIT_C123332 subClassOf NCIT_C201282 @default.
- NCIT_C123332 subClassOf NCIT_C20401 @default.
- NCIT_C123332 subClassOf NCIT_C274 @default.
- NCIT_C123332 subClassOf NCIT_C28227 @default.
- NCIT_C123332 subClassOf NCIT_C307 @default.
- NCIT_C123332 subClassOf NCIT_C308 @default.