Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C123362> ?p ?o ?g. }
Showing items 1 to 35 of
35
with 100 items per page.
- NCIT_C123362 IAO_0000115 "An orally bioavailable indolocarbazole derivative and inhibitor of constitutively active mutant forms of FMS-like tyrosine kinase 3 (FLT3) with potential antineoplastic activity. Following administration, FLT3 tyrosine kinase inhibitor TTT-3002 binds to and inhibits ligand-dependent dimerization and autophosphorylation of mutant forms of FLT3 with constitutively activating mutations, including FLT3 internal tandem duplication (FLT3/ITD) and the activating point mutation D835Y. Prevention of autophosphorylation inhibits uncontrolled FLT3 signaling and may result in the inhibition of proliferation in tumor cells expressing constitutively active mutant forms of FLT3. The ability of TTT-3002 to inhibit FLT3 proteins with activating point mutations may result in increased efficacy because the activity of these mutants are resistant to other FLT3 kinase inhibitors. FLT3, a tyrosine kinase receptor, plays a role in the regulation of hematopoietic progenitor cell proliferation, and in leukemic cell proliferation and survival. Constitutively activating mutations of FLT3 are the most frequent genetic alterations in acute myeloid leukemia." @default.
- NCIT_C123362 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123362 NCIT_A7 NCIT_C26202 @default.
- NCIT_C123362 NCIT_NHC0 "C123362" @default.
- NCIT_C123362 NCIT_P106 "Organic Chemical" @default.
- NCIT_C123362 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123362 NCIT_P107 "FLT3 Tyrosine Kinase Inhibitor TTT-3002" @default.
- NCIT_C123362 NCIT_P108 "FLT3 Tyrosine Kinase Inhibitor TTT-3002" @default.
- NCIT_C123362 NCIT_P207 "C3850293" @default.
- NCIT_C123362 NCIT_P322 "CTRP" @default.
- NCIT_C123362 NCIT_P322 "GDC" @default.
- NCIT_C123362 NCIT_P375 "FLT3 Tyrosine Kinase Inhibitor TTT-3002" @default.
- NCIT_C123362 normalizedInformationContent "100" @default.
- NCIT_C123362 referenceCount "1" @default.
- NCIT_C123362 hasExactSynonym "FLT3 Tyrosine Kinase Inhibitor TTT-3002" @default.
- NCIT_C123362 hasExactSynonym "TTT-3002" @default.
- NCIT_C123362 inSubset NCIT_C116977 @default.
- NCIT_C123362 inSubset NCIT_C116978 @default.
- NCIT_C123362 inSubset NCIT_C128784 @default.
- NCIT_C123362 inSubset NCIT_C157711 @default.
- NCIT_C123362 inSubset NCIT_C157712 @default.
- NCIT_C123362 inSubset NCIT_C177537 @default.
- NCIT_C123362 type Class @default.
- NCIT_C123362 isDefinedBy ncit.owl @default.
- NCIT_C123362 label "FLT3 Tyrosine Kinase Inhibitor TTT-3002" @default.
- NCIT_C123362 subClassOf NCIT_C123362 @default.
- NCIT_C123362 subClassOf NCIT_C124800 @default.
- NCIT_C123362 subClassOf NCIT_C1404 @default.
- NCIT_C123362 subClassOf NCIT_C163758 @default.
- NCIT_C123362 subClassOf NCIT_C163790 @default.
- NCIT_C123362 subClassOf NCIT_C1908 @default.
- NCIT_C123362 subClassOf NCIT_C1909 @default.
- NCIT_C123362 subClassOf NCIT_C1967 @default.
- NCIT_C123362 subClassOf NCIT_C274 @default.
- NCIT_C123362 subClassOf NCIT_C471 @default.