Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C123430> ?p ?o ?g. }
Showing items 1 to 31 of
31
with 100 items per page.
- NCIT_C123430 IAO_0000115 "An orally bioavailable sulfonamide urea derivative with antihyperglycemic activity. Upon administration, glibornuride binds to and blocks the sulfonylurea receptor type 1 (SUR1) subunit of the ATP-sensitive inwardly-rectifying potassium (K(ATP)) channels on the membranes of pancreatic beta cells. This prevents the inward flow of positively charged potassium (K+) ions into the cell, and induces a calcium ion (Ca2+) influx through voltage-sensitive calcium channels, which triggers exocytosis of insulin-containing granules. Insulin stimulates glycogen synthesis and inhibits gluconeogenesis, which together lower blood glucose levels." @default.
- NCIT_C123430 NCIT_NHC0 "C123430" @default.
- NCIT_C123430 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123430 NCIT_P108 "Glibornuride" @default.
- NCIT_C123430 NCIT_P207 "C0350998" @default.
- NCIT_C123430 NCIT_P210 "26944-48-9" @default.
- NCIT_C123430 NCIT_P319 "VP83E7434R" @default.
- NCIT_C123430 NCIT_P322 "FDA" @default.
- NCIT_C123430 NCIT_P329 "775332" @default.
- NCIT_C123430 NCIT_P330 "775332" @default.
- NCIT_C123430 NCIT_P399 "775332" @default.
- NCIT_C123430 normalizedInformationContent "100" @default.
- NCIT_C123430 referenceCount "1" @default.
- NCIT_C123430 hasExactSynonym "1-((1R)-2-endo-hydroxy-3-endo-bornyl)-3-(p-tolylsulfonyl)urea" @default.
- NCIT_C123430 hasExactSynonym "GLIBORNURIDE" @default.
- NCIT_C123430 hasExactSynonym "Glibornuride" @default.
- NCIT_C123430 hasExactSynonym "Glutril" @default.
- NCIT_C123430 hasExactSynonym "Ro 6-4563" @default.
- NCIT_C123430 hasExactSynonym "Ro 6-4563/8" @default.
- NCIT_C123430 hasExactSynonym "Urea, 1-(2-Hydroxy-3-bornyl)-3-(p-tolylsulfonyl)-, (1R,2R,3S,4S)-" @default.
- NCIT_C123430 inSubset NCIT_C176424 @default.
- NCIT_C123430 inSubset NCIT_C63923 @default.
- NCIT_C123430 type Class @default.
- NCIT_C123430 isDefinedBy ncit.owl @default.
- NCIT_C123430 label "Glibornuride" @default.
- NCIT_C123430 subClassOf NCIT_C123430 @default.
- NCIT_C123430 subClassOf NCIT_C1908 @default.
- NCIT_C123430 subClassOf NCIT_C1909 @default.
- NCIT_C123430 subClassOf NCIT_C29711 @default.
- NCIT_C123430 subClassOf NCIT_C78276 @default.
- NCIT_C123430 subClassOf NCIT_C97936 @default.