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- NCIT_C123649 IAO_0000115 "An immunotherapeutic agent composed of a fusion protein containing the human melanoma-associated antigen MAGE-A3 fused to a lipidated protein D derived from Haemophilus influenzae and combined with the immunoadjuvant AS15, with potential immunostimulating and antineoplastic activities. Upon intramuscular (IM) administration, GSK 2132231A may stimulate a specific cytotoxic T-lymphocyte (CTL) response against MAGE-A3-expressing tumor cells, resulting in tumor cell death. MAGE-A3, a tumor-associated antigen, is upregulated in a variety of cancer cell types. This fusion protein may boost antitumoral immune responses. AS15, a liposomal formulation containing the immunostimulating compounds CpG 7909, 3-O-desacyl-4'-monophosphoryl lipid A (MPL), and QS-21, increases the immune response against MAGE-A3-expressing tumors." @default.
- NCIT_C123649 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123649 NCIT_A7 NCIT_C17513 @default.
- NCIT_C123649 NCIT_NHC0 "C123649" @default.
- NCIT_C123649 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C123649 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123649 NCIT_P107 "MAGE-A3-specific Immunotherapeutic GSK 2132231A" @default.
- NCIT_C123649 NCIT_P108 "MAGE-A3-specific Immunotherapeutic GSK 2132231A" @default.
- NCIT_C123649 NCIT_P207 "C4053638" @default.
- NCIT_C123649 NCIT_P322 "CTRP" @default.
- NCIT_C123649 NCIT_P322 "GDC" @default.
- NCIT_C123649 NCIT_P375 "MAGE-A3-specific Immunotherapeutic GSK 2132231A" @default.
- NCIT_C123649 normalizedInformationContent "100" @default.
- NCIT_C123649 referenceCount "1" @default.
- NCIT_C123649 hasExactSynonym "ASCI GSK 2132231A" @default.
- NCIT_C123649 hasExactSynonym "Antigen Specific Cancer Immunotherapeutic GSK 2132231A" @default.
- NCIT_C123649 hasExactSynonym "GSK 2132231A" @default.
- NCIT_C123649 hasExactSynonym "GSK2132231A" @default.
- NCIT_C123649 hasExactSynonym "MAGE-A3 ASCI GSK 2132231A" @default.
- NCIT_C123649 hasExactSynonym "MAGE-A3-specific Immunotherapeutic GSK 2132231A" @default.
- NCIT_C123649 inSubset NCIT_C116977 @default.
- NCIT_C123649 inSubset NCIT_C116978 @default.
- NCIT_C123649 inSubset NCIT_C128784 @default.
- NCIT_C123649 inSubset NCIT_C157711 @default.
- NCIT_C123649 inSubset NCIT_C157712 @default.
- NCIT_C123649 inSubset NCIT_C177537 @default.
- NCIT_C123649 type Class @default.
- NCIT_C123649 isDefinedBy ncit.owl @default.
- NCIT_C123649 label "MAGE-A3-specific Immunotherapeutic GSK 2132231A" @default.
- NCIT_C123649 subClassOf NCIT_C123649 @default.
- NCIT_C123649 subClassOf NCIT_C129820 @default.
- NCIT_C123649 subClassOf NCIT_C1663 @default.
- NCIT_C123649 subClassOf NCIT_C1908 @default.
- NCIT_C123649 subClassOf NCIT_C1909 @default.
- NCIT_C123649 subClassOf NCIT_C274 @default.
- NCIT_C123649 subClassOf NCIT_C307 @default.
- NCIT_C123649 subClassOf NCIT_C308 @default.
- NCIT_C123649 subClassOf NCIT_C923 @default.