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- NCIT_C123722 IAO_0000115 "An orally available, irreversible inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, Hemay022 covalently binds to and inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C123722 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123722 NCIT_A7 NCIT_C17068 @default.
- NCIT_C123722 NCIT_NHC0 "C123722" @default.
- NCIT_C123722 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123722 NCIT_P108 "EGFR Antagonist Hemay022" @default.
- NCIT_C123722 NCIT_P207 "C4053636" @default.
- NCIT_C123722 NCIT_P322 "GDC" @default.
- NCIT_C123722 NCIT_P329 "775380" @default.
- NCIT_C123722 NCIT_P330 "775380" @default.
- NCIT_C123722 NCIT_P375 "EGFR Antagonist Hemay022" @default.
- NCIT_C123722 NCIT_P399 "775380" @default.
- NCIT_C123722 normalizedInformationContent "100" @default.
- NCIT_C123722 referenceCount "1" @default.
- NCIT_C123722 hasExactSynonym "EGFR Antagonist Hemay022" @default.
- NCIT_C123722 hasExactSynonym "EGFR Inhibitor Hemay022" @default.
- NCIT_C123722 hasExactSynonym "Hemay022" @default.
- NCIT_C123722 inSubset NCIT_C128784 @default.
- NCIT_C123722 inSubset NCIT_C157711 @default.
- NCIT_C123722 inSubset NCIT_C157712 @default.
- NCIT_C123722 inSubset NCIT_C176424 @default.
- NCIT_C123722 inSubset NCIT_C177537 @default.
- NCIT_C123722 type Class @default.
- NCIT_C123722 isDefinedBy ncit.owl @default.
- NCIT_C123722 label "EGFR Antagonist Hemay022" @default.
- NCIT_C123722 subClassOf NCIT_C123722 @default.
- NCIT_C123722 subClassOf NCIT_C129824 @default.
- NCIT_C123722 subClassOf NCIT_C129825 @default.
- NCIT_C123722 subClassOf NCIT_C1404 @default.
- NCIT_C123722 subClassOf NCIT_C163758 @default.
- NCIT_C123722 subClassOf NCIT_C163952 @default.
- NCIT_C123722 subClassOf NCIT_C1908 @default.
- NCIT_C123722 subClassOf NCIT_C1909 @default.
- NCIT_C123722 subClassOf NCIT_C1967 @default.
- NCIT_C123722 subClassOf NCIT_C2167 @default.
- NCIT_C123722 subClassOf NCIT_C2189 @default.
- NCIT_C123722 subClassOf NCIT_C274 @default.
- NCIT_C123722 subClassOf NCIT_C471 @default.