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- NCIT_C123724 IAO_0000115 "Human autologous mesenchymal stem cells (MSCs) harvested from the bone marrow of healthy individuals and transduced with a retroviral vector encoding the human cytokine interferon beta (IFNb), with potential immunomodulating and antineoplastic activities. Upon administration of IFNb-secreting MSCs, the cells are attracted and specifically migrate to tumor sites and become part of the tumor microenvironment. Since the MSCs express IFNb, these cells selectively deliver high levels of IFNb to the tumor site. In turn, IFNb binds to IFN-specific cell surface receptors and modulates the transcription and translation of certain genes whose protein products are involved in tumor cell proliferation. This decreases tumor cell growth." @default.
- NCIT_C123724 NCIT_NHC0 "C123724" @default.
- NCIT_C123724 NCIT_P106 "Cell" @default.
- NCIT_C123724 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123724 NCIT_P107 "Interferon Beta-secreting Mesenchymal Stem Cells" @default.
- NCIT_C123724 NCIT_P108 "Interferon Beta-secreting Mesenchymal Stem Cells" @default.
- NCIT_C123724 NCIT_P207 "C4053520" @default.
- NCIT_C123724 NCIT_P322 "CTRP" @default.
- NCIT_C123724 NCIT_P329 "775579" @default.
- NCIT_C123724 NCIT_P330 "775579" @default.
- NCIT_C123724 NCIT_P399 "775579" @default.
- NCIT_C123724 normalizedInformationContent "100" @default.
- NCIT_C123724 referenceCount "1" @default.
- NCIT_C123724 hasExactSynonym "IFNb-MSC" @default.
- NCIT_C123724 hasExactSynonym "IFNb-secreting MSCs" @default.
- NCIT_C123724 hasExactSynonym "IFNbeta-MSC" @default.
- NCIT_C123724 hasExactSynonym "Interferon Beta-secreting Mesenchymal Stem Cells" @default.
- NCIT_C123724 hasExactSynonym "MSC-IFN beta" @default.
- NCIT_C123724 inSubset NCIT_C116977 @default.
- NCIT_C123724 inSubset NCIT_C116978 @default.
- NCIT_C123724 inSubset NCIT_C128784 @default.
- NCIT_C123724 inSubset NCIT_C176424 @default.
- NCIT_C123724 type Class @default.
- NCIT_C123724 isDefinedBy ncit.owl @default.
- NCIT_C123724 label "Interferon Beta-secreting Mesenchymal Stem Cells" @default.
- NCIT_C123724 subClassOf NCIT_C123724 @default.
- NCIT_C123724 subClassOf NCIT_C129820 @default.
- NCIT_C123724 subClassOf NCIT_C129821 @default.
- NCIT_C123724 subClassOf NCIT_C129826 @default.
- NCIT_C123724 subClassOf NCIT_C142078 @default.
- NCIT_C123724 subClassOf NCIT_C1908 @default.
- NCIT_C123724 subClassOf NCIT_C1909 @default.
- NCIT_C123724 subClassOf NCIT_C201556 @default.
- NCIT_C123724 subClassOf NCIT_C274 @default.
- NCIT_C123724 subClassOf NCIT_C307 @default.
- NCIT_C123724 subClassOf NCIT_C308 @default.