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- NCIT_C123734 IAO_0000115 "A humanized monoclonal antibody agonist of the cell surface receptor CD40, with potential immunostimulatory and antineoplastic activities. Similar to the endogenous CD40 ligand (CD40L or CD154), sotigalimab binds to CD40 on a variety of immune cell types. This triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B-cells, and effector and memory T-cells. This results in an enhanced immune response against tumor cells. Sotigalimab also binds to and activates CD40 present on the surfaces of some solid tumor cells, leading to apoptosis and decreased tumor growth. CD40, a cell surface receptor and member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various immune cells and certain cancer cells; it mediates both indirect tumor cell killing through the activation of the immune system and direct tumor cell apoptosis." @default.
- NCIT_C123734 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123734 NCIT_A7 NCIT_C17281 @default.
- NCIT_C123734 NCIT_NHC0 "C123734" @default.
- NCIT_C123734 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C123734 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C123734 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123734 NCIT_P107 "Sotigalimab" @default.
- NCIT_C123734 NCIT_P108 "Sotigalimab" @default.
- NCIT_C123734 NCIT_P207 "C4053581" @default.
- NCIT_C123734 NCIT_P210 "2305607-45-6" @default.
- NCIT_C123734 NCIT_P319 "JEA93WJ5DG" @default.
- NCIT_C123734 NCIT_P322 "CTRP" @default.
- NCIT_C123734 NCIT_P322 "FDA" @default.
- NCIT_C123734 NCIT_P322 "GDC" @default.
- NCIT_C123734 NCIT_P329 "775520" @default.
- NCIT_C123734 NCIT_P330 "775520" @default.
- NCIT_C123734 NCIT_P375 "CD40 Agonistic Monoclonal Antibody APX005M" @default.
- NCIT_C123734 NCIT_P375 "Sotigalimab" @default.
- NCIT_C123734 NCIT_P399 "775520" @default.
- NCIT_C123734 NCIT_R124 NCIT_C17710 @default.
- NCIT_C123734 NCIT_R124 NCIT_C17828 @default.
- NCIT_C123734 NCIT_R124 NCIT_C18219 @default.
- NCIT_C123734 NCIT_R124 NCIT_C19986 @default.
- NCIT_C123734 NCIT_R124 NCIT_C40474 @default.
- NCIT_C123734 normalizedInformationContent "100" @default.
- NCIT_C123734 referenceCount "1" @default.
- NCIT_C123734 hasExactSynonym "APX 005" @default.
- NCIT_C123734 hasExactSynonym "APX 005M" @default.
- NCIT_C123734 hasExactSynonym "APX-005M" @default.
- NCIT_C123734 hasExactSynonym "APX005M" @default.
- NCIT_C123734 hasExactSynonym "CD40 Agonistic Monoclonal Antibody APX005M" @default.
- NCIT_C123734 hasExactSynonym "EPI-0050" @default.
- NCIT_C123734 hasExactSynonym "SOTIGALIMAB" @default.
- NCIT_C123734 hasExactSynonym "Sotigalimab" @default.
- NCIT_C123734 inSubset NCIT_C116977 @default.
- NCIT_C123734 inSubset NCIT_C116978 @default.
- NCIT_C123734 inSubset NCIT_C128784 @default.
- NCIT_C123734 inSubset NCIT_C157711 @default.
- NCIT_C123734 inSubset NCIT_C157712 @default.
- NCIT_C123734 inSubset NCIT_C176424 @default.
- NCIT_C123734 inSubset NCIT_C177537 @default.
- NCIT_C123734 inSubset NCIT_C63923 @default.
- NCIT_C123734 type Class @default.
- NCIT_C123734 isDefinedBy ncit.owl @default.
- NCIT_C123734 label "Sotigalimab" @default.
- NCIT_C123734 subClassOf NCIT_C123734 @default.
- NCIT_C123734 subClassOf NCIT_C129820 @default.
- NCIT_C123734 subClassOf NCIT_C133877 @default.
- NCIT_C123734 subClassOf NCIT_C1908 @default.
- NCIT_C123734 subClassOf NCIT_C1909 @default.
- NCIT_C123734 subClassOf NCIT_C191767 @default.
- NCIT_C123734 subClassOf NCIT_C20401 @default.
- NCIT_C123734 subClassOf NCIT_C274 @default.
- NCIT_C123734 subClassOf NCIT_C307 @default.
- NCIT_C123734 subClassOf NCIT_C308 @default.