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- NCIT_C123765 IAO_0000115 "Epidermal growth factor receptor protein (EGFR) bearing phosphorylated tyrosine residues within the 194 amino acids of the carboxyl-terminal intracellular domain of the protein. Five ligand-dependent autophosphorylation sites have been identified; overexpression or mutation of EGFR can decouple ligand-binding from autophosphorylation and the subsequent activation of downstream signaling pathways. The presence of phosphorylated EGFR in a malignant tumor is generally correlated with poor prognosis and could be used as a predictive biomarker to identify individuals who may respond to EGFR-tyrosine kinase inhibitor treatment." @default.
- NCIT_C123765 NCIT_A13 NCIT_C17757 @default.
- NCIT_C123765 NCIT_NHC0 "C123765" @default.
- NCIT_C123765 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C123765 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C123765 NCIT_P107 "Phosphorylated Epidermal Growth Factor Receptor" @default.
- NCIT_C123765 NCIT_P108 "Phosphorylated Epidermal Growth Factor Receptor" @default.
- NCIT_C123765 NCIT_P207 "C1655202" @default.
- NCIT_C123765 NCIT_P322 "CTRP" @default.
- NCIT_C123765 normalizedInformationContent "100" @default.
- NCIT_C123765 referenceCount "1" @default.
- NCIT_C123765 hasExactSynonym "Autophosphorylated Epidermal Growth Factor Receptor" @default.
- NCIT_C123765 hasExactSynonym "Phospho-EGFR" @default.
- NCIT_C123765 hasExactSynonym "Phosphorylated EGFR" @default.
- NCIT_C123765 hasExactSynonym "Phosphorylated Epidermal Growth Factor Receptor" @default.
- NCIT_C123765 hasExactSynonym "p-EGFR" @default.
- NCIT_C123765 hasExactSynonym "pEGFR" @default.
- NCIT_C123765 inSubset NCIT_C116977 @default.
- NCIT_C123765 inSubset NCIT_C142799 @default.
- NCIT_C123765 inSubset NCIT_C142800 @default.
- NCIT_C123765 type Class @default.
- NCIT_C123765 isDefinedBy ncit.owl @default.
- NCIT_C123765 label "Phosphorylated Epidermal Growth Factor Receptor" @default.
- NCIT_C123765 subClassOf NCIT_C123765 @default.
- NCIT_C123765 subClassOf NCIT_C16342 @default.
- NCIT_C123765 subClassOf NCIT_C20047 @default.
- NCIT_C123765 subClassOf NCIT_C20069 @default.