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- NCIT_C123816 IAO_0000115 "A monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1,) with immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1 monoclonal antibody SHR-1210 binds to and blocks the binding of PD-1, expressed on activated T-lymphocytes, B-cells and natural killer (NK) cells, to its ligands programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen presenting cells (APCs). This prevents the activation of PD-1 and its downstream signaling pathways. This restores immune function through the activation of cytotoxic T-lymphocytes (CTLs) and cell-mediated immune responses against tumor cells or pathogens. Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity." @default.
- NCIT_C123816 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123816 NCIT_A7 NCIT_C94697 @default.
- NCIT_C123816 NCIT_NHC0 "C123816" @default.
- NCIT_C123816 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C123816 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C123816 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123816 NCIT_P107 "Camrelizumab" @default.
- NCIT_C123816 NCIT_P108 "Camrelizumab" @default.
- NCIT_C123816 NCIT_P208 "CL498210" @default.
- NCIT_C123816 NCIT_P210 "1798286-48-2" @default.
- NCIT_C123816 NCIT_P319 "73096E137E" @default.
- NCIT_C123816 NCIT_P322 "CTRP" @default.
- NCIT_C123816 NCIT_P322 "FDA" @default.
- NCIT_C123816 NCIT_P322 "GDC" @default.
- NCIT_C123816 NCIT_P329 "775449" @default.
- NCIT_C123816 NCIT_P330 "775449" @default.
- NCIT_C123816 NCIT_P375 "Camrelizumab" @default.
- NCIT_C123816 NCIT_P399 "775449" @default.
- NCIT_C123816 NCIT_R124 NCIT_C17710 @default.
- NCIT_C123816 NCIT_R124 NCIT_C17828 @default.
- NCIT_C123816 NCIT_R124 NCIT_C18219 @default.
- NCIT_C123816 NCIT_R124 NCIT_C19986 @default.
- NCIT_C123816 NCIT_R124 NCIT_C40474 @default.
- NCIT_C123816 normalizedInformationContent "100" @default.
- NCIT_C123816 referenceCount "1" @default.
- NCIT_C123816 hasExactSynonym "AiRuiKa (TM)" @default.
- NCIT_C123816 hasExactSynonym "AiRuiKa" @default.
- NCIT_C123816 hasExactSynonym "CAMRELIZUMAB" @default.
- NCIT_C123816 hasExactSynonym "Camrelizumab" @default.
- NCIT_C123816 hasExactSynonym "Carrizumab" @default.
- NCIT_C123816 hasExactSynonym "HR-301210" @default.
- NCIT_C123816 hasExactSynonym "SHR 1210" @default.
- NCIT_C123816 hasExactSynonym "SHR-1210" @default.
- NCIT_C123816 hasExactSynonym "SHR1210" @default.
- NCIT_C123816 inSubset NCIT_C116977 @default.
- NCIT_C123816 inSubset NCIT_C116978 @default.
- NCIT_C123816 inSubset NCIT_C128784 @default.
- NCIT_C123816 inSubset NCIT_C157711 @default.
- NCIT_C123816 inSubset NCIT_C157712 @default.
- NCIT_C123816 inSubset NCIT_C176424 @default.
- NCIT_C123816 inSubset NCIT_C177537 @default.
- NCIT_C123816 inSubset NCIT_C63923 @default.
- NCIT_C123816 type Class @default.
- NCIT_C123816 isDefinedBy ncit.owl @default.
- NCIT_C123816 label "Camrelizumab" @default.
- NCIT_C123816 subClassOf NCIT_C123816 @default.
- NCIT_C123816 subClassOf NCIT_C124946 @default.
- NCIT_C123816 subClassOf NCIT_C128037 @default.
- NCIT_C123816 subClassOf NCIT_C129821 @default.
- NCIT_C123816 subClassOf NCIT_C129822 @default.
- NCIT_C123816 subClassOf NCIT_C141144 @default.
- NCIT_C123816 subClassOf NCIT_C143250 @default.
- NCIT_C123816 subClassOf NCIT_C163758 @default.
- NCIT_C123816 subClassOf NCIT_C1908 @default.
- NCIT_C123816 subClassOf NCIT_C1909 @default.
- NCIT_C123816 subClassOf NCIT_C20401 @default.
- NCIT_C123816 subClassOf NCIT_C274 @default.
- NCIT_C123816 subClassOf NCIT_C307 @default.
- NCIT_C123816 subClassOf NCIT_C308 @default.