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- NCIT_C123819 IAO_0000115 "A preparation of autologous dendritic cells (DC) mixed with cytokine-induced killer (CIK) cells (DC-CIK), with potential immunopotentiating and antineoplastic activities. DCs were obtained ex vivo by incubation of peripheral blood lymphocytes (PBLs) with granulocyte-macrophage colony-stimulating factor stimulating factor (GM-CSF or CSF2), tumor necrosis factor (TNF), and interleukin (IL)-24 and were sensitized with tumor-associated antigens (TAAs). Cytokine-induced killer (CIK) cells are immune effector cells with both T-cell and natural killer (NK) cell like phenotype. CIKs are non-major histocompatibility complex (MHC)-restricted, NK-like T-lymphocytes, which express both CD3, a T-cell surface marker, and CD56, a natural killer cell surface marker, and have been generated ex vivo by incubation of peripheral blood lymphocytes (PBLs) with anti-CD3 monoclonal antibody, IL-2, IL-1 alpha, and interferon gamma (IFN-gamma) and then expanded. Upon co-culture of DCs and CIKs, and administration of DC-CIK cells into the patient, the DCs are able to stimulate the immune response to exert a specific anti-tumor immune response, while the CIK cells exert direct oncolytic activity." @default.
- NCIT_C123819 NCIT_NHC0 "C123819" @default.
- NCIT_C123819 NCIT_P106 "Cell" @default.
- NCIT_C123819 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123819 NCIT_P108 "Therapeutic Dendritic Cells/Cytokine-induced Killer Cells" @default.
- NCIT_C123819 NCIT_P208 "CL498213" @default.
- NCIT_C123819 NCIT_P329 "775528" @default.
- NCIT_C123819 NCIT_P330 "775528" @default.
- NCIT_C123819 NCIT_P399 "775528" @default.
- NCIT_C123819 normalizedInformationContent "100" @default.
- NCIT_C123819 referenceCount "1" @default.
- NCIT_C123819 hasExactSynonym "DC-CIK" @default.
- NCIT_C123819 hasExactSynonym "Therapeutic Dendritic Cells/Cytokine-induced Killer Cells" @default.
- NCIT_C123819 inSubset NCIT_C128784 @default.
- NCIT_C123819 inSubset NCIT_C176424 @default.
- NCIT_C123819 type Class @default.
- NCIT_C123819 isDefinedBy ncit.owl @default.
- NCIT_C123819 label "Therapeutic Dendritic Cells/Cytokine-induced Killer Cells" @default.
- NCIT_C123819 subClassOf NCIT_C123819 @default.
- NCIT_C123819 subClassOf NCIT_C129820 @default.
- NCIT_C123819 subClassOf NCIT_C129821 @default.
- NCIT_C123819 subClassOf NCIT_C129826 @default.
- NCIT_C123819 subClassOf NCIT_C142078 @default.
- NCIT_C123819 subClassOf NCIT_C1908 @default.
- NCIT_C123819 subClassOf NCIT_C1909 @default.
- NCIT_C123819 subClassOf NCIT_C2139 @default.
- NCIT_C123819 subClassOf NCIT_C274 @default.
- NCIT_C123819 subClassOf NCIT_C307 @default.
- NCIT_C123819 subClassOf NCIT_C308 @default.