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- NCIT_C123827 IAO_0000115 "An orally bioavailable inhibitor of specific mutated forms of platelet-derived growth factor receptor alpha (PDGFR alpha; PDGFRa) and mast/stem cell factor receptor c-Kit (SCFR), with potential antineoplastic activity. Upon oral administration, avapritinib specifically binds to and inhibits specific mutant forms of PDGFRa and c-Kit, including the PDGFRa D842V mutant and various KIT exon 17 mutants. This results in the inhibition of PDGFRa- and c-Kit-mediated signal transduction pathways and the inhibition of proliferation in tumor cells that express these PDGFRa and c-Kit mutants. PDGFRa and c-Kit, protein tyrosine kinases and tumor-associated antigens (TAAs), are mutated in various tumor cell types; they play key roles in the regulation of cellular proliferation." @default.
- NCIT_C123827 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123827 NCIT_A7 NCIT_C17328 @default.
- NCIT_C123827 NCIT_A7 NCIT_C30163 @default.
- NCIT_C123827 NCIT_NHC0 "C123827" @default.
- NCIT_C123827 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123827 NCIT_P107 "Avapritinib" @default.
- NCIT_C123827 NCIT_P108 "Avapritinib" @default.
- NCIT_C123827 NCIT_P208 "CL498221" @default.
- NCIT_C123827 NCIT_P210 "1703793-34-3" @default.
- NCIT_C123827 NCIT_P302 "Treatment of Adults with Unresectable or Metastatic Gastrointestinal Stromal Tumor Harboring a Platelet-derived Growth Factor Receptor Alpha Exon 18 Mutation" @default.
- NCIT_C123827 NCIT_P319 "513P80B4YJ" @default.
- NCIT_C123827 NCIT_P322 "CTRP" @default.
- NCIT_C123827 NCIT_P322 "FDA" @default.
- NCIT_C123827 NCIT_P322 "GDC" @default.
- NCIT_C123827 NCIT_P329 "775630" @default.
- NCIT_C123827 NCIT_P330 "775630" @default.
- NCIT_C123827 NCIT_P375 "Avapritinib" @default.
- NCIT_C123827 NCIT_P399 "775630" @default.
- NCIT_C123827 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C123827 referenceCount "2" @default.
- NCIT_C123827 hasExactSynonym "(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1Hpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-yl)pyrimidin-5-yl)ethan-1-amine" @default.
- NCIT_C123827 hasExactSynonym "AVAPRITINIB" @default.
- NCIT_C123827 hasExactSynonym "AYVAKIT" @default.
- NCIT_C123827 hasExactSynonym "Avapritinib" @default.
- NCIT_C123827 hasExactSynonym "Ayvakyt" @default.
- NCIT_C123827 hasExactSynonym "BLU-285" @default.
- NCIT_C123827 hasExactSynonym "CS3007" @default.
- NCIT_C123827 hasExactSynonym "PDGFR alpha/KIT Mutant-specific Inhibitor BLU-285" @default.
- NCIT_C123827 inSubset NCIT_C116977 @default.
- NCIT_C123827 inSubset NCIT_C116978 @default.
- NCIT_C123827 inSubset NCIT_C128784 @default.
- NCIT_C123827 inSubset NCIT_C157711 @default.
- NCIT_C123827 inSubset NCIT_C157712 @default.
- NCIT_C123827 inSubset NCIT_C176424 @default.
- NCIT_C123827 inSubset NCIT_C177537 @default.
- NCIT_C123827 inSubset NCIT_C63923 @default.
- NCIT_C123827 type Class @default.
- NCIT_C123827 isDefinedBy ncit.owl @default.
- NCIT_C123827 label "Avapritinib" @default.
- NCIT_C123827 subClassOf NCIT_C123827 @default.
- NCIT_C123827 subClassOf NCIT_C129824 @default.
- NCIT_C123827 subClassOf NCIT_C129825 @default.
- NCIT_C123827 subClassOf NCIT_C1404 @default.
- NCIT_C123827 subClassOf NCIT_C159198 @default.
- NCIT_C123827 subClassOf NCIT_C159199 @default.
- NCIT_C123827 subClassOf NCIT_C163758 @default.
- NCIT_C123827 subClassOf NCIT_C163999 @default.
- NCIT_C123827 subClassOf NCIT_C164037 @default.
- NCIT_C123827 subClassOf NCIT_C1908 @default.
- NCIT_C123827 subClassOf NCIT_C1909 @default.
- NCIT_C123827 subClassOf NCIT_C1967 @default.
- NCIT_C123827 subClassOf NCIT_C2189 @default.
- NCIT_C123827 subClassOf NCIT_C274 @default.
- NCIT_C123827 subClassOf NCIT_C471 @default.