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- NCIT_C123828 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody against human inactive tyrosine-protein kinase 7 (PTK7) linked, via a cleavable valine-citrulline linker, to an analog of the auristatin microtubule inhibitor dolastatin 10, auristatin-0101, with potential antineoplastic activity. Upon administration, cofetuzumab pelidotin targets and binds to PTK7 expressed on tumor cells. Upon binding, internalization and cleavage, auristatin-0101 binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and apoptosis of PTK7-expressing tumor cells. PTK7, a tumor-associated antigen (TAA), is overexpressed on a variety of cancer cells." @default.
- NCIT_C123828 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123828 NCIT_A7 NCIT_C34330 @default.
- NCIT_C123828 NCIT_NHC0 "C123828" @default.
- NCIT_C123828 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123828 NCIT_P107 "Cofetuzumab Pelidotin" @default.
- NCIT_C123828 NCIT_P108 "Cofetuzumab Pelidotin" @default.
- NCIT_C123828 NCIT_P208 "CL474137" @default.
- NCIT_C123828 NCIT_P210 "1869937-48-3" @default.
- NCIT_C123828 NCIT_P319 "249EAP69MT" @default.
- NCIT_C123828 NCIT_P322 "CTRP" @default.
- NCIT_C123828 NCIT_P322 "FDA" @default.
- NCIT_C123828 NCIT_P322 "GDC" @default.
- NCIT_C123828 NCIT_P329 "764236" @default.
- NCIT_C123828 NCIT_P330 "764236" @default.
- NCIT_C123828 NCIT_P375 "Anti-PTK7/Auristatin-0101 Antibody-drug Conjugate PF-06647020" @default.
- NCIT_C123828 NCIT_P375 "Cofetuzumab Pelidotin" @default.
- NCIT_C123828 NCIT_P399 "764236" @default.
- NCIT_C123828 normalizedInformationContent "100" @default.
- NCIT_C123828 referenceCount "1" @default.
- NCIT_C123828 hasExactSynonym "ADC PF-06647020" @default.
- NCIT_C123828 hasExactSynonym "ADC PF-7020" @default.
- NCIT_C123828 hasExactSynonym "COFETUZUMAB PELIDOTIN" @default.
- NCIT_C123828 hasExactSynonym "Cofetuzumab Pelidotin" @default.
- NCIT_C123828 hasExactSynonym "Immunoglobulin G1, Anti-(human protein tyrosine kinase 7) (humanized Mus musculus clone hu24 gamma-chain), Disulfide with humanized Mus musculus clone hu24 kappa-chain, Dimer, Thioether with N-(((4-((N-(6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl)-L-valyl-N5-(aminocarbonyl)-L-ornithyl)amino)phenyl)methoxy)carbonyl)-2-methylalanyl-N-((1S,2R)-2-methoxy-4-((2S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((1S)-2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-((1S)-1-methylpropyl)-4-oxobutyl)-N-methyl-L-valinamide" @default.
- NCIT_C123828 hasExactSynonym "PF 06647020" @default.
- NCIT_C123828 hasExactSynonym "PF 7020" @default.
- NCIT_C123828 hasExactSynonym "PF-06647020" @default.
- NCIT_C123828 hasExactSynonym "PF-7020" @default.
- NCIT_C123828 hasExactSynonym "PF06647020" @default.
- NCIT_C123828 hasExactSynonym "h6M24-vc0101" @default.
- NCIT_C123828 inSubset NCIT_C116977 @default.
- NCIT_C123828 inSubset NCIT_C116978 @default.
- NCIT_C123828 inSubset NCIT_C128784 @default.
- NCIT_C123828 inSubset NCIT_C157711 @default.
- NCIT_C123828 inSubset NCIT_C157712 @default.
- NCIT_C123828 inSubset NCIT_C176424 @default.
- NCIT_C123828 inSubset NCIT_C177537 @default.
- NCIT_C123828 inSubset NCIT_C63923 @default.
- NCIT_C123828 type Class @default.
- NCIT_C123828 isDefinedBy ncit.owl @default.
- NCIT_C123828 label "Cofetuzumab Pelidotin" @default.
- NCIT_C123828 subClassOf NCIT_C123828 @default.
- NCIT_C123828 subClassOf NCIT_C129821 @default.
- NCIT_C123828 subClassOf NCIT_C129823 @default.
- NCIT_C123828 subClassOf NCIT_C1512 @default.
- NCIT_C123828 subClassOf NCIT_C1908 @default.
- NCIT_C123828 subClassOf NCIT_C1909 @default.
- NCIT_C123828 subClassOf NCIT_C274 @default.
- NCIT_C123828 subClassOf NCIT_C307 @default.
- NCIT_C123828 subClassOf NCIT_C308 @default.