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- NCIT_C123830 IAO_0000115 "An orally bioavailable inhibitor of the membrane-bound O-acyltransferase (MBOAT) porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, ETC-1922159 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational palmitoylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine catalyzes the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion. Wnt signaling is dysregulated in a variety of cancers." @default.
- NCIT_C123830 NCIT_A32 NCIT_C1909 @default.
- NCIT_C123830 NCIT_A7 NCIT_C132191 @default.
- NCIT_C123830 NCIT_NHC0 "C123830" @default.
- NCIT_C123830 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123830 NCIT_P107 "Porcupine Inhibitor ETC-1922159" @default.
- NCIT_C123830 NCIT_P108 "Porcupine Inhibitor ETC-1922159" @default.
- NCIT_C123830 NCIT_P208 "CL498223" @default.
- NCIT_C123830 NCIT_P210 "1638250-96-0" @default.
- NCIT_C123830 NCIT_P319 "5L854240DQ" @default.
- NCIT_C123830 NCIT_P322 "CTRP" @default.
- NCIT_C123830 NCIT_P322 "FDA" @default.
- NCIT_C123830 NCIT_P322 "GDC" @default.
- NCIT_C123830 NCIT_P329 "775936" @default.
- NCIT_C123830 NCIT_P330 "775936" @default.
- NCIT_C123830 NCIT_P375 "Porcupine Inhibitor ETC-1922159" @default.
- NCIT_C123830 NCIT_P399 "775936" @default.
- NCIT_C123830 normalizedInformationContent "100" @default.
- NCIT_C123830 referenceCount "1" @default.
- NCIT_C123830 hasExactSynonym "ETC-159" @default.
- NCIT_C123830 hasExactSynonym "ETC-1922159" @default.
- NCIT_C123830 hasExactSynonym "PORCN Inhibitor ETC-1922159" @default.
- NCIT_C123830 hasExactSynonym "Porcupine Inhibitor ETC-1922159" @default.
- NCIT_C123830 inSubset NCIT_C116977 @default.
- NCIT_C123830 inSubset NCIT_C116978 @default.
- NCIT_C123830 inSubset NCIT_C128784 @default.
- NCIT_C123830 inSubset NCIT_C157711 @default.
- NCIT_C123830 inSubset NCIT_C157712 @default.
- NCIT_C123830 inSubset NCIT_C176424 @default.
- NCIT_C123830 inSubset NCIT_C177537 @default.
- NCIT_C123830 inSubset NCIT_C63923 @default.
- NCIT_C123830 type Class @default.
- NCIT_C123830 isDefinedBy ncit.owl @default.
- NCIT_C123830 label "Porcupine Inhibitor ETC-1922159" @default.
- NCIT_C123830 subClassOf NCIT_C123830 @default.
- NCIT_C123830 subClassOf NCIT_C1908 @default.
- NCIT_C123830 subClassOf NCIT_C1909 @default.
- NCIT_C123830 subClassOf NCIT_C471 @default.