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- NCIT_C123879 IAO_0000115 "An orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential activity against HCV genotype 1. Upon administration, paritaprevir reversibly binds to the active center and binding site of the HCV NS3/NS4A protease and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts both the processing of viral proteins and the formation of the viral replication complex, which inhibits viral replication in HCV genotype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavage of multiple sites within the HCV polyprotein and plays a key role during HCV ribonucleic acid (RNA) replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family, and infection is associated with the development of hepatocellular carcinoma (HCC)." @default.
- NCIT_C123879 NCIT_NHC0 "C123879" @default.
- NCIT_C123879 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C123879 NCIT_P107 "Paritaprevir" @default.
- NCIT_C123879 NCIT_P108 "Paritaprevir" @default.
- NCIT_C123879 NCIT_P207 "C3712108" @default.
- NCIT_C123879 NCIT_P210 "1216941-48-8" @default.
- NCIT_C123879 NCIT_P319 "OU2YM37K86" @default.
- NCIT_C123879 NCIT_P322 "CTRP" @default.
- NCIT_C123879 NCIT_P322 "FDA" @default.
- NCIT_C123879 normalizedInformationContent "100" @default.
- NCIT_C123879 referenceCount "1" @default.
- NCIT_C123879 hasExactSynonym "(2R,6S,12Z,13aS,14aR,16aS)-N-(Cyclopropylsulfonyl)-6-{[(5-methyl-2-pyrazinyl)carbonyl]amino}-5,16-dioxo-2-(6-phenanthridinyloxy)-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo [1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide" @default.
- NCIT_C123879 hasExactSynonym "ABT 450" @default.
- NCIT_C123879 hasExactSynonym "ABT-450" @default.
- NCIT_C123879 hasExactSynonym "ABT450" @default.
- NCIT_C123879 hasExactSynonym "PARITAPREVIR" @default.
- NCIT_C123879 hasExactSynonym "Paritaprevir" @default.
- NCIT_C123879 hasExactSynonym "Veruprevir" @default.
- NCIT_C123879 inSubset NCIT_C116977 @default.
- NCIT_C123879 inSubset NCIT_C116978 @default.
- NCIT_C123879 inSubset NCIT_C63923 @default.
- NCIT_C123879 type Class @default.
- NCIT_C123879 isDefinedBy ncit.owl @default.
- NCIT_C123879 label "Paritaprevir" @default.
- NCIT_C123879 subClassOf NCIT_C123879 @default.
- NCIT_C123879 subClassOf NCIT_C1908 @default.
- NCIT_C123879 subClassOf NCIT_C1909 @default.
- NCIT_C123879 subClassOf NCIT_C471 @default.
- NCIT_C123879 subClassOf NCIT_C783 @default.